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The aim of this project is to identify common genetic polymorphisms associated with the occurrence of rhythmic events in patients with severe cardiomyopathy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Appropriate treatment | Patients who have a rhythmic event (before or after inclusion) appropriately treated either by administering an electric shock or by antiarrhythmic stimulation |
| |
| No event | Patients who have never received treatment or electrical antiarrhythmic stimulation and with a minimum follow-up of three years before inclusion and did not receive appropriate treatment during the follow up period of the study. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Identification of genetic polymorphisms | Genetic |
|
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of polymorphisms pre-selected candidates (or by direct sequencing by High Resolution Melting). | 4 years | |
| Identification of polymorphisms frequent (> 5% in the general population) by association study ( "Genome Wide Association Study '(GWAS)) using genotyping technology broadband Axiom (Affymetrix). | 4 years |
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Inclusion Criteria:
Exclusion Criteria:
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Genetic analysis will compare 500 patients implanted with an ICD for primary prevention and having received an appropriate shock and another 500 patients implanted with an ICD for primary prevention and have not received appropriate shock after a minimum follow-up three years before inclusion. To allow the matching of two groups, it requires to recruit 500 patients in the "appropriate treatment" group and 1000 patients in the "no event" group.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Angers | Angers | France | ||||
| CHU Bordeaux |
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| Bordeaux |
| France |
| CHU Brest | Brest | France |
| CHU Clermont-Ferrand. | Clermont-Ferrand | France |
| CHU Dijon | Dijon | France |
| CHU Grenoble | Grenoble | France |
| CH La Rochelle | La Rochelle | France |
| CHRU Lille | Lille | France |
| CHU Lyon | Lyon | France |
| CHU Marseille | Marseille | France |
| CHU Montpellier | Montpellier | France |
| CHU Nancy | Nancy | France |
| CHU Nantes | Nantes | France |
| CHU Rennes | Rennes | France |
| CHU Rouen | Rouen | France |
| CHRU Strasbourg | Strasbourg | France |
| CHU Toulouse | Toulouse | France |
| CHU Tours | Tours | France |
| ID | Term |
|---|---|
| D009202 | Cardiomyopathies |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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