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| ID | Type | Description | Link |
|---|---|---|---|
| R01AG054077 | U.S. NIH Grant/Contract | View source | |
| RF1AG071469 | U.S. NIH Grant/Contract | View source | |
| AWD00532 | Other Identifier | UFIRST |
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| Name | Class |
|---|---|
| University of Arizona | OTHER |
| National Institute on Aging (NIA) | NIH |
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A two-phase adaptive randomized clinical trial will examine the individual and combined impact of pairing cognitive training with transcranial direct current stimulation (tDCS). tDCS is a method of non-invasive brain stimulation that directly stimulates brain regions involved in active cognitive function and could enhance neural plasticity when paired with a training task. We will compare changes in cognitive and brain function resulting from CT and ET combined with tDCS using a comprehensive neurocognitive, clinical, and multimodal neuroimaging assessment of brain structure, function, and metabolic state. Functional magnetic resonance imaging (FMRI) will be used to assess brain response during working memory, attention, and memory encoding; the active cognitive abilities trained by CT. Proton magnetic resonance spectroscopy (MRS) will assess cerebral metabolites, including GABA concentrations sensitive to neural plasticity. We hypothesize that: 1) tDCS will enhance neurocognitive function, brain function, and functional outcomes from CT, with combined CT and tDCS providing the most benefit; 2) Effects of tDCS on CT will be maintained up to 12 months following training, and 3) Neuroimaging biomarkers of cerebral metabolism, neural plasticity (GABA concentrations) and functional brain response (FMRI) during resting vs. active cognitive tasks will predict individual response to tDCS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cognitive Training + Active Stimulation | Experimental | This arm receives cognitive training combined with active tDCS. |
|
| Cognitive Training + Sham Stimulation | Experimental | This arm receives cognitive training combined with sham tDCS. |
|
| Educational Training + Active Stimulation | Experimental | This arm receives educational training combined with active tDCS. |
|
| Educational Training + Sham Stimulation | Experimental | This arm receives educational training combined with sham tDCS. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cognitive Training | Behavioral | Cognitive Training employs an eight component, PositScience BrainHQ suite via its researcher portal. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Improvement in Cognitive Ability. | Composite measure of cognitive ability as defined by NIH toolbox fluid cognition fully corrected T-score. Minimum change = -13, Maximum change = 26. Higher scores mean a better outcome. The minimum and maximum for Cognitive Training + Active Stimulation, Cognitive Training + Sham Stimulation, Educational Training + Active Stimulation and Educational Training + Sham Stimulation are (-13, 20) and (-10, 26), respectively. This outcome is measured for the participants who received cognitive training, including both Phase I and Phase II participants, N=334 (Phase I N=42, Phase II N=292). | Change from baseline to post assessment (3 months). |
| Measure | Description | Time Frame |
|---|---|---|
| Phase I POSIT BrainHQ Cognitive Training Composite Performance Measure.(Phase I POSIT Z-Score) | POSIT BrainHQ Cognitive Training Composite Performance measure involves performance on the 8 selected cognitive training tasks set to the medium difficulty level and provides a measure of proximal performance on cognitive training tasks central to the cognitive training condition. The higher score indicates better performance. The range of POSIT Z-Score at 3-month is -1.04 to 1.75. the minimum and maximum for Cognitive training group and Education training group are (-0.24, 1.75) and (-1.04, 1.39), respectively. |
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Inclusion criteria:
Exclusion criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Adam Woods, Ph.D | University of Florida | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Arizona | Tucson | Arizona | 85721 | United States | ||
| Village of Gainesville |
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Participant flow is reported with three periods. Period 1 includes all randomized participants (combined Phase I and Phase II). Period 2 contains only the Phase I participants. Period 3 contains only the Phase II participants.
In Phase II the two education training arms were eliminated, hence the allocation of 0 to those groups. Participants who were enrolled in Phase I education training were not randomized again in Phase II (there is no crossover).
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| ID | Title | Description |
|---|---|---|
| FG000 | Cognitive Training + Active Stimulation | This arm receives cognitive training combined with active tDCS. Cognitive Training: Cognitive Training employs an eight component, PositScience BrainHQ suite via its researcher portal. tDCS (active stimulation): A Soterix Clinical Trials Direct Current Stimulator will apply 20 minutes of 2.0mA direct current through two biocarbon rubber electrodes encased in saline soaked 5cm x 7cm sponges (8cc of 0.9% saline solution per sponge) placed over the frontal cortices at F3 and F4 (10-20 system). |
| FG001 | Cognitive Training + Sham Stimulation | This arm receives cognitive training combined with sham tDCS. Cognitive Training: Cognitive Training employs an eight component, PositScience BrainHQ suite via its researcher portal. tDCS (sham stimulation): Sham stimulation is performed with the same device and all procedures will be identical except for the duration of stimulation. Participants will receive 30 seconds of 2 mA of direct current stimulation at the beginning of the session. Participants habituate to the sensation of tDCS within 30-60 seconds of stimulation. This procedure provides the same sensation of tDCS without the full duration of stimulation, making it a highly effective sham procedure. |
| FG002 | Educational Training + Active Stimulation | This arm receives educational training combined with active tDCS. tDCS (active stimulation): A Soterix Clinical Trials Direct Current Stimulator will apply 20 minutes of 2.0mA direct current through two biocarbon rubber electrodes encased in saline soaked 5cm x 7cm sponges (8cc of 0.9% saline solution per sponge) placed over the frontal cortices at F3 and F4 (10-20 system). Educational Training: Educational training involves watching educational videos produced by the National Geographic Channel, which cover a range of topics such as history, nature, and wildlife. Participants will be asked to complete questions on the content of the videos to ensure sustained attention. |
| FG003 | Educational Training + Sham Stimulation | This arm receives educational training combined with sham tDCS. tDCS (sham stimulation): Sham stimulation is performed with the same device and all procedures will be identical except for the duration of stimulation. Participants will receive 30 seconds of 2 mA of direct current stimulation at the beginning of the session. Participants habituate to the sensation of tDCS within 30-60 seconds of stimulation. This procedure provides the same sensation of tDCS without the full duration of stimulation, making it a highly effective sham procedure. Educational Training: Educational training involves watching educational videos produced by the National Geographic Channel, which cover a range of topics such as history, nature, and wildlife. Participants will be asked to complete questions on the content of the videos to ensure sustained attention. |
| Title | Milestones | Reasons Not Completed | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall (Phase I + Phase II) |
|
| ||||||||||||||||||
| Phase I |
| |||||||||||||||||||
| Phase II |
|
The study is a 2-phase adaptive design study. After first phase, 2 education arms were dropped. all participants were randomly assigned to 2 cognitive training groups in Phase II.
Not provided
| ID | Title | Description |
|---|---|---|
| BG000 | Cognitive Training + Active Stimulation | This arm receives cognitive training combined with active tDCS. Cognitive Training: Cognitive Training employs an eight component, PositScience BrainHQ suite via its researcher portal. tDCS (active stimulation): A Soterix Clinical Trials Direct Current Stimulator will apply 20 minutes of 2.0mA direct current through two biocarbon rubber electrodes encased in saline soaked 5cm x 7cm sponges (8cc of 0.9% saline solution per sponge) placed over the frontal cortices at F3 and F4 (10-20 system). |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Improvement in Cognitive Ability. | Composite measure of cognitive ability as defined by NIH toolbox fluid cognition fully corrected T-score. Minimum change = -13, Maximum change = 26. Higher scores mean a better outcome. The minimum and maximum for Cognitive Training + Active Stimulation, Cognitive Training + Sham Stimulation, Educational Training + Active Stimulation and Educational Training + Sham Stimulation are (-13, 20) and (-10, 26), respectively. This outcome is measured for the participants who received cognitive training, including both Phase I and Phase II participants, N=334 (Phase I N=42, Phase II N=292). | Posted | Mean | Standard Deviation | units on a scale | Change from baseline to post assessment (3 months). |
|
The adverse events were collected over an approximate one year period. They were collected from study enrollment until the 1 year followup visit.
Adverse events were queried using medical history questionnaires at baseline, 3 month post test, and 1 follow-up assessment visits. If adverse events were self reported by participants between assessment visits a standardized adverse event form was completed to assess severity, relatedness, and outcome.
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Cognitive Training + Active Stimulation | This arm receives cognitive training combined with active tDCS. Cognitive Training: Cognitive Training employs an eight component, PositScience BrainHQ suite via its researcher portal. tDCS (active stimulation): A Soterix Clinical Trials Direct Current Stimulator will apply 20 minutes of 2.0mA direct current through two biocarbon rubber electrodes encased in saline soaked 5cm x 7cm sponges (8cc of 0.9% saline solution per sponge) placed over the frontal cortices at F3 and F4 (10-20 system). |
| Term | Organ System | Source Vocabulary | Assessment Type | Notes | Statistical Information |
|---|---|---|---|---|---|
| Accidentally swallowed non food item | Gastrointestinal disorders | Non-systematic Assessment |
| Term | Organ System | Source Vocabulary | Assessment Type | Notes | Statistical Information |
|---|---|---|---|---|---|
| Actinic Keratoses | Skin and subcutaneous tissue disorders | Non-systematic Assessment |
Not provided
| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Adam Woods, Ph.D. | University of Florida | 352-294-5842 | ajwoods@phhp.ufl.edu |
Not provided
| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Jun 16, 2021 | Apr 26, 2023 | Prot_SAP_000.pdf |
| ICF | No | No | Yes | Informed Consent Form | Feb 11, 2019 | Apr 15, 2024 | ICF_001.pdf |
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| ID | Term |
|---|---|
| D000091942 | Cognitive Training |
| D065908 | Transcranial Direct Current Stimulation |
| D014146 | Training Support |
| ID | Term |
|---|---|
| D000066530 | Neurological Rehabilitation |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
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| tDCS (active stimulation) | Device | A Soterix Clinical Trials Direct Current Stimulator will apply 20 minutes of 2.0mA direct current through two biocarbon rubber electrodes encased in saline soaked 5cm x 7cm sponges (8cc of 0.9% saline solution per sponge) placed over the frontal cortices at F3 and F4 (10-20 system). |
|
| tDCS (sham stimulation) | Device | Sham stimulation is performed with the same device and all procedures will be identical except for the duration of stimulation. Participants will receive 30 seconds of 2 mA of direct current stimulation at the beginning of the session. Participants habituate to the sensation of tDCS within 30-60 seconds of stimulation. This procedure provides the same sensation of tDCS without the full duration of stimulation, making it a highly effective sham procedure. |
|
| Educational Training | Behavioral | Educational training involves watching educational videos produced by the National Geographic Channel, which cover a range of topics such as history, nature, and wildlife. Participants will be asked to complete questions on the content of the videos to ensure sustained attention. |
|
| Baseline to post assessment (3 months). |
| Gainesville |
| Florida |
| 32606 |
| United States |
| University of Florida McKnight Brain Institute | Gainesville | Florida | 32610 | United States |
| Withdrawal by Subject |
|
| COVID-19 lockdown, no reason specified |
|
| Lost to Follow-up |
|
| COMPLETED |
|
| NOT COMPLETED |
|
|
| COMPLETED |
|
| NOT COMPLETED |
|
|
| BG001 | Cognitive Training + Sham Stimulation | This arm receives cognitive training combined with sham tDCS. Cognitive Training: Cognitive Training employs an eight component, PositScience BrainHQ suite via its researcher portal. tDCS (sham stimulation): Sham stimulation is performed with the same device and all procedures will be identical except for the duration of stimulation. Participants will receive 30 seconds of 2 mA of direct current stimulation at the beginning of the session. Participants habituate to the sensation of tDCS within 30-60 seconds of stimulation. This procedure provides the same sensation of tDCS without the full duration of stimulation, making it a highly effective sham procedure. |
| BG002 | Educational Training + Active Stimulation | This arm receives educational training combined with active tDCS. tDCS (active stimulation): A Soterix Clinical Trials Direct Current Stimulator will apply 20 minutes of 2.0mA direct current through two biocarbon rubber electrodes encased in saline soaked 5cm x 7cm sponges (8cc of 0.9% saline solution per sponge) placed over the frontal cortices at F3 and F4 (10-20 system). Educational Training: Educational training involves watching educational videos produced by the National Geographic Channel, which cover a range of topics such as history, nature, and wildlife. Participants will be asked to complete questions on the content of the videos to ensure sustained attention. |
| BG003 | Educational Training + Sham Stimulation | This arm receives educational training combined with sham tDCS. tDCS (sham stimulation): Sham stimulation is performed with the same device and all procedures will be identical except for the duration of stimulation. Participants will receive 30 seconds of 2 mA of direct current stimulation at the beginning of the session. Participants habituate to the sensation of tDCS within 30-60 seconds of stimulation. This procedure provides the same sensation of tDCS without the full duration of stimulation, making it a highly effective sham procedure. Educational Training: Educational training involves watching educational videos produced by the National Geographic Channel, which cover a range of topics such as history, nature, and wildlife. Participants will be asked to complete questions on the content of the videos to ensure sustained attention. |
| BG004 | Total | Total of all reporting groups |
| years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Ethnicity (NIH/OMB) | Count of Participants | Participants |
|
| Race (NIH/OMB) | Count of Participants | Participants |
|
| Region of Enrollment | Number | participants |
|
| Years of Education | Mean | Standard Deviation | years |
|
| MOCA Total Score | Montreal Cognitive Assessment (MOCA) was designed as a rapid screening instrument for the detection of mild cognitive impairment. Higher scores indicate better cognition. The possible range of scores is 0 to 30. The total score is calculated by summing scores from the following domains: visuospatial/executive, naming, attention, language, abstraction, delayed recall, and orientation. | Mean | Standard Deviation | units on a scale |
|
| Average POSIT z-score: | POSIT BrainHQ Cognitive Training Composite Performance Measure (POSIT Z-Score) involves performance on the 8 selected cognitive training tasks set to the medium difficulty level and provides a measure of proximal performance on cognitive training tasks central to the cognitive training condition. A value of 0 represents mean performance as expected by age normative data. Higher positive values represent better than expected cognitive performance. | Mean | Standard Deviation | z-score |
|
| BDI-II Total Score | Beck Depression Inventory-II (BDI-II) measures the severity of depression in adolescents and adults. The total score ranges from 0 to 63 with higher scores indicating more severe depressive symptoms. Scores from 21 individual items are summed to create a total score. | Mean | Standard Deviation | units on a scale |
|
| OG001 | Cognitive Training + Sham Stimulation | This arm receives cognitive training combined with sham tDCS. Cognitive Training: Cognitive Training employs an eight component, PositScience BrainHQ suite via its researcher portal. tDCS (sham stimulation): Sham stimulation is performed with the same device and all procedures will be identical except for the duration of stimulation. Participants will receive 30 seconds of 2 mA of direct current stimulation at the beginning of the session. Participants habituate to the sensation of tDCS within 30-60 seconds of stimulation. This procedure provides the same sensation of tDCS without the full duration of stimulation, making it a highly effective sham procedure. |
|
|
|
| Secondary | Phase I POSIT BrainHQ Cognitive Training Composite Performance Measure.(Phase I POSIT Z-Score) | POSIT BrainHQ Cognitive Training Composite Performance measure involves performance on the 8 selected cognitive training tasks set to the medium difficulty level and provides a measure of proximal performance on cognitive training tasks central to the cognitive training condition. The higher score indicates better performance. The range of POSIT Z-Score at 3-month is -1.04 to 1.75. the minimum and maximum for Cognitive training group and Education training group are (-0.24, 1.75) and (-1.04, 1.39), respectively. | Adults were between the ages of 65-89, right-handed, fluent in English, and had evidence of age-related cognitive decline. Analysis includes all 87 participants from Phase I. | Posted | Mean | Standard Deviation | units on a scale | Baseline to post assessment (3 months). |
|
|
|
| 0 |
| 168 |
| 16 |
| 168 |
| 69 |
| 168 |
| EG001 | Cognitive Training + Sham Stimulation | This arm receives cognitive training combined with sham tDCS. Cognitive Training: Cognitive Training employs an eight component, PositScience BrainHQ suite via its researcher portal. tDCS (sham stimulation): Sham stimulation is performed with the same device and all procedures will be identical except for the duration of stimulation. Participants will receive 30 seconds of 2 mA of direct current stimulation at the beginning of the session. Participants habituate to the sensation of tDCS within 30-60 seconds of stimulation. This procedure provides the same sensation of tDCS without the full duration of stimulation, making it a highly effective sham procedure. | 0 | 166 | 19 | 166 | 75 | 166 |
| EG002 | Educational Training + Active Stimulation | This arm receives educational training combined with active tDCS. tDCS (active stimulation): A Soterix Clinical Trials Direct Current Stimulator will apply 20 minutes of 2.0mA direct current through two biocarbon rubber electrodes encased in saline soaked 5cm x 7cm sponges (8cc of 0.9% saline solution per sponge) placed over the frontal cortices at F3 and F4 (10-20 system). Educational Training: Educational training involves watching educational videos produced by the National Geographic Channel, which cover a range of topics such as history, nature, and wildlife. Participants will be asked to complete questions on the content of the videos to ensure sustained attention. | 0 | 23 | 4 | 23 | 12 | 23 |
| EG003 | Educational Training + Sham Stimulation | This arm receives educational training combined with sham tDCS. tDCS (sham stimulation): Sham stimulation is performed with the same device and all procedures will be identical except for the duration of stimulation. Participants will receive 30 seconds of 2 mA of direct current stimulation at the beginning of the session. Participants habituate to the sensation of tDCS within 30-60 seconds of stimulation. This procedure provides the same sensation of tDCS without the full duration of stimulation, making it a highly effective sham procedure. Educational Training: Educational training involves watching educational videos produced by the National Geographic Channel, which cover a range of topics such as history, nature, and wildlife. Participants will be asked to complete questions on the content of the videos to ensure sustained attention. | 0 | 22 | 5 | 22 | 12 | 22 |
| Allergic reaction | Skin and subcutaneous tissue disorders | Non-systematic Assessment |
|
| Anterior and posterior surgery (pelvic floor) | Surgical and medical procedures | Non-systematic Assessment |
|
| Asthma | Respiratory, thoracic and mediastinal disorders | Non-systematic Assessment |
|
| Atrial Fibrillation | Cardiac disorders | Non-systematic Assessment |
|
| Bleeding | Eye disorders | Non-systematic Assessment |
|
| Blood Loss | Renal and urinary disorders | Non-systematic Assessment |
|
| Bowel Obstruction | Gastrointestinal disorders | Non-systematic Assessment |
|
| Bowel infection | Infections and infestations | Non-systematic Assessment |
|
| Broken finger | Musculoskeletal and connective tissue disorders | Non-systematic Assessment |
|
| Bronchitis | Respiratory, thoracic and mediastinal disorders | Non-systematic Assessment |
|
| Cat bite | Infections and infestations | Non-systematic Assessment |
|
| Cellulitis | Skin and subcutaneous tissue disorders | Non-systematic Assessment |
|
| Chest Pain | Cardiac disorders | Non-systematic Assessment |
|
| Cut on cheek (stiches) | Skin and subcutaneous tissue disorders | Non-systematic Assessment |
|
| Cyst removal | Skin and subcutaneous tissue disorders | Non-systematic Assessment |
|
| Dislocated Shoulder | Musculoskeletal and connective tissue disorders | Non-systematic Assessment |
|
| Esophageal cancer | Gastrointestinal disorders | Non-systematic Assessment |
|
| Eye injury | Eye disorders | Non-systematic Assessment |
|
| Fall | General disorders | Non-systematic Assessment |
|
| Fall (fractured finger) | Musculoskeletal and connective tissue disorders | Non-systematic Assessment |
|
| Fecal blockage | Gastrointestinal disorders | Non-systematic Assessment |
|
| Finger injury | Musculoskeletal and connective tissue disorders | Non-systematic Assessment |
|
| Foot fracture | Musculoskeletal and connective tissue disorders | Non-systematic Assessment |
|
| Hernia | Gastrointestinal disorders | Non-systematic Assessment |
|
| Herniated disc repair | Musculoskeletal and connective tissue disorders | Non-systematic Assessment |
|
| Infection from Knee Replacement | Infections and infestations | Non-systematic Assessment |
|
| Infection from skin wound | Infections and infestations | Non-systematic Assessment |
|
| Intestinal Bleeding | Gastrointestinal disorders | Non-systematic Assessment |
|
| Pneumonia | Respiratory, thoracic and mediastinal disorders | Non-systematic Assessment |
|
| Prostate Cancer | Reproductive system and breast disorders | Non-systematic Assessment |
|
| Pulmonary Embolism | Vascular disorders | Non-systematic Assessment |
|
| Rapid heartbeat (ER visit) | Cardiac disorders | Non-systematic Assessment |
|
| Shingles | Skin and subcutaneous tissue disorders | Non-systematic Assessment |
|
| Shortness of Breath, tunnel vision, lost continence (ER visit) | General disorders | Non-systematic Assessment |
|
| Skin cancer spot removal | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | Non-systematic Assessment |
|
| Stitches | Skin and subcutaneous tissue disorders | Non-systematic Assessment |
|
| Stomach bleeding | Gastrointestinal disorders | Non-systematic Assessment |
|
| Stomach pain | Gastrointestinal disorders | Non-systematic Assessment |
|
| Tachycardia | Cardiac disorders | Non-systematic Assessment |
|
| Torn artery | Vascular disorders | Non-systematic Assessment |
|
| Transient ischemic attack | Vascular disorders | Non-systematic Assessment |
|
| Urine retention | Renal and urinary disorders | Non-systematic Assessment |
|
| Vertigo | Nervous system disorders | Non-systematic Assessment |
|
| Anemia | Blood and lymphatic system disorders | Non-systematic Assessment |
|
| Anxiety | Psychiatric disorders | Non-systematic Assessment |
|
| Anxiety and Depression | Psychiatric disorders | Non-systematic Assessment |
|
| Arrhythmia | Cardiac disorders | Non-systematic Assessment |
|
| Arthritis | Musculoskeletal and connective tissue disorders | Non-systematic Assessment |
|
| Atrial Fibrillation | Cardiac disorders | Non-systematic Assessment |
|
| Back pain (urgent care visit) | Musculoskeletal and connective tissue disorders | Non-systematic Assessment |
|
| Bipolar Disorder Treatment | Psychiatric disorders | Non-systematic Assessment |
|
| Bladder infection | Renal and urinary disorders | Non-systematic Assessment |
|
| Bone fusion of finger | Metabolism and nutrition disorders | Non-systematic Assessment |
|
| Bone spur (foot) | Musculoskeletal and connective tissue disorders | Non-systematic Assessment |
|
| Bone spurs on knees | Musculoskeletal and connective tissue disorders | Non-systematic Assessment |
|
| Breast Cancer | Reproductive system and breast disorders | Non-systematic Assessment |
|
| Broken bone in hand from fall | Musculoskeletal and connective tissue disorders | Non-systematic Assessment |
|
| Broken wrist | Musculoskeletal and connective tissue disorders | Non-systematic Assessment |
|
| Bronchiectasis | Respiratory, thoracic and mediastinal disorders | Non-systematic Assessment |
|
| Bronchitis | Respiratory, thoracic and mediastinal disorders | Non-systematic Assessment |
|
| Bruised rib | Musculoskeletal and connective tissue disorders | Non-systematic Assessment |
|
| COVID-19 | Infections and infestations | Non-systematic Assessment |
|
| Cataract surgery | Surgical and medical procedures | Non-systematic Assessment |
|
| Cataracts | Eye disorders | Non-systematic Assessment |
|
| Cellulitis | Skin and subcutaneous tissue disorders | Non-systematic Assessment |
|
| Chest Pain | Cardiac disorders | Non-systematic Assessment |
|
| Chest pain (caused by esophogeal gastritis and hiatal hernia) | Gastrointestinal disorders | Non-systematic Assessment |
|
| Colonoscopy | Surgical and medical procedures | Non-systematic Assessment |
|
| Concussion | Nervous system disorders | Non-systematic Assessment |
|
| Conjunctivitis | Eye disorders | Non-systematic Assessment |
|
| Coronary artery disease | Cardiac disorders | Non-systematic Assessment |
|
| Cough / Allergies | Respiratory, thoracic and mediastinal disorders | Non-systematic Assessment |
|
| Cut on head | Skin and subcutaneous tissue disorders | Non-systematic Assessment |
|
| Dehydration | Metabolism and nutrition disorders | Non-systematic Assessment |
|
| Depression | Psychiatric disorders | Non-systematic Assessment |
|
| Dizziness | General disorders | Non-systematic Assessment |
|
| Dysphagia | Gastrointestinal disorders | Non-systematic Assessment |
|
| Enlarged prostate | Reproductive system and breast disorders | Non-systematic Assessment |
|
| Eustachian tube dysfunction | Ear and labyrinth disorders | Non-systematic Assessment |
|
| Eye hemorrhage | Eye disorders | Non-systematic Assessment |
|
| Eye injury | Eye disorders | Non-systematic Assessment |
|
| Eyelid surgery | Surgical and medical procedures | Non-systematic Assessment |
|
| Fainting | Nervous system disorders | Non-systematic Assessment |
|
| Fainting (post blood draw unrelated to study) | General disorders | Non-systematic Assessment |
|
| Fall | General disorders | Non-systematic Assessment |
|
| Fall (hit front of head) | General disorders | Non-systematic Assessment |
|
| Finger numbness | Musculoskeletal and connective tissue disorders | Non-systematic Assessment |
|
| Food poisoning | Gastrointestinal disorders | Non-systematic Assessment |
|
| Foot Injury | Musculoskeletal and connective tissue disorders | Non-systematic Assessment |
|
| Fractured hand | Musculoskeletal and connective tissue disorders | Non-systematic Assessment |
|
| Headache | Nervous system disorders | Non-systematic Assessment |
|
| Hearing impairment | Ear and labyrinth disorders | Non-systematic Assessment |
|
| Hearing loss | Ear and labyrinth disorders | Non-systematic Assessment |
|
| Heart Ablation | Cardiac disorders | Non-systematic Assessment |
|
| Heart Murmur | Cardiac disorders | Non-systematic Assessment |
|
| Heart palpitations | Cardiac disorders | Non-systematic Assessment |
|
| Heat Exhaustion | General disorders | Non-systematic Assessment |
|
| Hernia | Gastrointestinal disorders | Non-systematic Assessment |
|
| High Blood Pressure | Cardiac disorders | Non-systematic Assessment |
|
| High Cholesterol | General disorders | Non-systematic Assessment |
|
| High blood pressure and low heart rate | Cardiac disorders | Non-systematic Assessment |
|
| Hip Replacement | Surgical and medical procedures | Non-systematic Assessment |
|
| Hip injury | Musculoskeletal and connective tissue disorders | Non-systematic Assessment |
|
| Hypothyroidism | Endocrine disorders | Non-systematic Assessment |
|
| Kidney Cyst | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | Non-systematic Assessment |
|
| Kidney stones | Renal and urinary disorders | Non-systematic Assessment |
|
| Knee Pain | Musculoskeletal and connective tissue disorders | Non-systematic Assessment |
|
| Knee and hip pain | Musculoskeletal and connective tissue disorders | Non-systematic Assessment |
|
| Knee injury | Musculoskeletal and connective tissue disorders | Non-systematic Assessment |
|
| Larynopharyngeal reflux | Gastrointestinal disorders | Non-systematic Assessment |
|
| Low Iron | Metabolism and nutrition disorders | Non-systematic Assessment |
|
| Macular degeneration | Eye disorders | Non-systematic Assessment |
|
| Migraine headache | Nervous system disorders | Non-systematic Assessment |
|
| Mononucleosis | Infections and infestations | Non-systematic Assessment |
|
| Nasal Drip | General disorders | Non-systematic Assessment |
|
| Nausea | Gastrointestinal disorders | Non-systematic Assessment |
|
| Nausea and Dizziness | General disorders | Non-systematic Assessment |
|
| Neck Injury from car accident | Musculoskeletal and connective tissue disorders | Non-systematic Assessment |
|
| Oral surgery | Surgical and medical procedures | Non-systematic Assessment |
|
| PTSD & Increased Anxiety | Psychiatric disorders | Non-systematic Assessment |
|
| Paronychia | Skin and subcutaneous tissue disorders | Non-systematic Assessment |
|
| Posterior Vitreous Detachment | Eye disorders | Non-systematic Assessment |
|
| Prostatitis | Reproductive system and breast disorders | Non-systematic Assessment |
|
| Protruding Disc (L5) | Musculoskeletal and connective tissue disorders | Non-systematic Assessment |
|
| Radio ablation | Surgical and medical procedures | Non-systematic Assessment |
|
| Rash | Skin and subcutaneous tissue disorders | Non-systematic Assessment |
|
| Renal failure | Renal and urinary disorders | Non-systematic Assessment |
|
| Sciatica | Musculoskeletal and connective tissue disorders | Non-systematic Assessment |
|
| Shingles | Skin and subcutaneous tissue disorders | Non-systematic Assessment |
|
| Shoulder pain | Musculoskeletal and connective tissue disorders | Non-systematic Assessment |
|
| Skin biopsy | Surgical and medical procedures | Non-systematic Assessment |
|
| Skin cancer spot removal | Surgical and medical procedures | Non-systematic Assessment |
|
| Spinal Stenosis | Musculoskeletal and connective tissue disorders | Non-systematic Assessment |
|
| Spinal Stenosis & Sciatica | Musculoskeletal and connective tissue disorders | Non-systematic Assessment |
|
| Stents | Cardiac disorders | Non-systematic Assessment |
|
| Stress fracture (fibula) | Musculoskeletal and connective tissue disorders | Non-systematic Assessment |
|
| Sty | Eye disorders | Non-systematic Assessment |
|
| Tachycardia | Cardiac disorders | Non-systematic Assessment |
|
| Tendonitis | Musculoskeletal and connective tissue disorders | Non-systematic Assessment |
|
| Thoracic Aortic Aneurysm | Vascular disorders | Non-systematic Assessment |
|
| Urinary tract infection | Renal and urinary disorders | Non-systematic Assessment |
|
| Urolift implant (Enlarged Prostate treatment) | Surgical and medical procedures | Non-systematic Assessment |
|
| Varithena Ablation | Surgical and medical procedures | Non-systematic Assessment |
|
| Varithena treatment | Surgical and medical procedures | Non-systematic Assessment |
|
| Vertigo | Nervous system disorders | Non-systematic Assessment |
|
| Wrist pain | Musculoskeletal and connective tissue disorders | Non-systematic Assessment |
|
| Wrist surgery | Surgical and medical procedures | Non-systematic Assessment |
|
Not provided
Not provided
Not provided
| D005791 |
| Patient Care |
| D013812 | Therapeutics |
| D006296 | Health Services |
| D005159 | Health Care Facilities Workforce and Services |
| D004599 | Electric Stimulation Therapy |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |
| D005378 | Financial Support |
| D004467 | Economics |
| D004472 | Health Care Economics and Organizations |