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NO is an ubiquitous molecule contributing to many physiological functions such as vasodilation, immune and oxidative stress responses. NO production can be supplemented either by providing substrate to the NO-synthase (L-Arginine and L-Citruline) or by providing nitrate which can lead to NO. In the present project the investigators evaluate the effect of various acute and chronic oral NO precursors supplementation on exercise performance and responses in healthy young and older subjects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Acute intake | Active Comparator | Evaluation after acute intake of the food supplement. |
|
| Chronic intake | Active Comparator | Evaluation before and after chronic intake of the food supplement. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nitrate | Dietary Supplement | Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with NO precursors. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Neuromuscular evaluations | After the intake of the supplement. Measure the stretching force in the ankle (N) | 3 half days |
| Evaluation of post-ischemic vascular reactivity | After the intake of the supplement. Concentration of hemoglobin (g/mL) in the quadriceps with the device : NIRS system Oxymon, ARTINIS. | 3 half days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Stéphane Doutreleau, PhD | University Hospital, Grenoble | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Grenoble University Hospital | Grenoble | Auvergne-Rhône-Alpes | 38043 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24791915 | Background | Jones AM. Dietary nitrate supplementation and exercise performance. Sports Med. 2014 May;44 Suppl 1(Suppl 1):S35-45. doi: 10.1007/s40279-014-0149-y. | |
| 24650698 | Background | Kapil V, Weitzberg E, Lundberg JO, Ahluwalia A. Clinical evidence demonstrating the utility of inorganic nitrate in cardiovascular health. Nitric Oxide. 2014 Apr 30;38:45-57. doi: 10.1016/j.niox.2014.03.162. Epub 2014 Mar 18. |
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| ID | Term |
|---|---|
| D009566 | Nitrates |
| D001120 | Arginine |
| D002956 | Citrulline |
| ID | Term |
|---|---|
| D000838 | Anions |
| D007477 | Ions |
| D004573 | Electrolytes |
| D007287 | Inorganic Chemicals |
| D017942 |
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| Nitrate and L-Arginine | Dietary Supplement | Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with NO precursors. |
|
| Nitrate and L-Citrulline | Dietary Supplement | Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with NO precursors. |
|
| Placebo | Dietary Supplement | Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with a placebo. |
|
| Evaluation of post-ischemic vascular reactivity | Biological | After the intake of the supplement. Concentration of hemoglobin (g/mL) in the quadriceps with the device : NIRS system Oxymon, ARTINIS. |
|
| Neuromuscular evaluations | Biological | After the intake of the supplement. Measure the stretching force in the ankle (N) |
|
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| 33064413 | Result | LE Roux-Mallouf T, Vallejo A, Pelen F, Halimaoui I, Doutreleau S, Verges S. Synergetic Effect of NO Precursor Supplementation and Exercise Training. Med Sci Sports Exerc. 2020 Nov;52(11):2437-2447. doi: 10.1249/MSS.0000000000002387. |
| Nitric Acid |
| D017672 | Nitrogen Compounds |
| D009930 | Organic Chemicals |
| D024361 | Amino Acids, Basic |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |
| D000599 | Amino Acids, Diamino |
| D000601 | Amino Acids, Essential |