Effect of NO Precursors on Physiological Responses to Exercise

The Effect of NO Precursors on Physiological Responses to Exercise

NO is an ubiquitous molecule contributing to many physiological functions such as vasodilation, immune and oxidative stress responses. NO production can be supplemented either by providing substrate to the NO-synthase (L-Arginine and L-Citruline) or by providing nitrate which can lead to NO. In the present project the investigators evaluate the effect of various acute and chronic oral NO precursors supplementation on exercise performance and responses in healthy young and older subjects.

Inclusion Criteria:

• Sedentary subjects
• No cardiovascular, respiratory, metabolic and neurological disorders

Exclusion Criteria:

• Body mass index > 28 kg.m-2
• Smoker
• Alcool intake > 10g/day
• Psychiatric diseases
• Subjects under treatment able to interfere with their cardiovascular, metabolic and neurological status