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With the repercussion of 55 cases eachyear for 100 000 inhabitants in France, cardio respiratory arrest is a public health issue.
The goal of this study is to evaluate the pupillary light reflex measured by the dimension of the pupil (diameter) as a prognosis factor neurological evolution in post cardiac arrest. By participating to this study, the patient get the same tratments and exams than in a usual managing cares.
In addition of these events, the pupillary light reflex is studied as soon as the patient is accepted in the department, and then on the second day.
Currently, the evaluation of the neurological becoming rely on a multimodal clinical and paraclinical approach.
The study of the pupillary light reflex measured by the diameter of the pupil could be a prognosis factor of neurological evolution for patients in post cardiac arrest, so a reliable and available prognosis marker in patient care.
The goal of this study is to evaluate the pupillary light reflex (RPM), measured by the diameter of the pupil as a prognosis factor of neurological evaluation of admitted patients after a cardiac arrest.
Principal criteria of judgement is the percentage of the pupillary light reflex variation measured with Neurolight®, compared between two groups.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Favourable neurological evolution after cardiac arrest | Active Comparator | MGOS 4-5 |
|
| Unfavourable neurological evolution after cardiac arrest | Active Comparator | MGOS 1-3 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Therapeutic hypothermia | Other | With a mattress at 4°C to reach a central temperature at 33,5°C. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of the pupillary light reflex variation measured with Neurolight® | Compared between two groups. Favourable neurological evolution after cardiac arrest : MGOS 4-5 Unfavourable neurological evolution after cardiac arrest MGOS 1-3 | One second |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Michel Durand, Doctor | Grenoble Hospital University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UniversityHospitalGrenoble | La Tronche | 38700 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
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| Synchronized Intermittent Mandatory Ventilation | Device | Constant volume 6 ml/kg |
|
|
| Electroencephalography | Other |
|
|
| Pupillary light reflex surveillance | Device | With Neurolight® device. |
|
| Transcranial Doppler | Device | Monitoring tool for brain hemodynamic evaluation. With Philips HD15 Ultrasound system®. |
|
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| ID | Term |
|---|---|
| D006323 | Heart Arrest |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D007036 | Hypothermia, Induced |
| D017585 | Ultrasonography, Doppler, Transcranial |
| ID | Term |
|---|---|
| D017679 | Cryotherapy |
| D013812 | Therapeutics |
| D004453 | Echoencephalography |
| D009485 | Neuroradiography |
| D059906 | Neuroimaging |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011859 | Radiography |
| D014463 | Ultrasonography |
| D018608 | Ultrasonography, Doppler |
| D003943 | Diagnostic Techniques, Neurological |
| D008919 | Investigative Techniques |
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