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This study investigates the levels of advanced oxidation protein product and monocyte chemoattractant protein-1 in gingival crevicular fluid in periodontal disease and health. 25 participants with chronic periodontitis, 25 participants with gingivitis and 25 periodontally healthy subjects are included into this study. In each participant, four sites are identified for gingival crevicular fluid samples.
Oxidative stress is the disequilibrium between the formation of free radicals and antioxidant defense mechanisms via damaging cellular macromolecules (DNA, protein, lipid, etc..) which are susceptible to oxidative damage.
Advanced oxidation protein product is identified as a new marker of protein oxidation.
Monocyte chemoattractant protein-1 is a major chemoattractant for lymphocytes, monocytes and macrophages.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Chronic periodontitis group | Subjects who have moderate to severe alveolar bone loss and clinical attachment level (CAL) ≥5 mm and probing depth (PD) ≥6mm in multiple sites of all four quadrants of the mouth but with no evidence of rapid progression | ||
| Gingivitis group | Subjects who show gingival inflammation that is based on the presence of bleeding on probing (BOP) at >50% of sites in the whole mouth, no clinical and radiographic signs of periodontitis | ||
| Periodontally healthy group | Subjects who have no sites with PD >3mm and CAL >0 mm, a BOP score of <15% at the examination and no alveolar bone loss. |
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| Measure | Description | Time Frame |
|---|---|---|
| Advanced oxidation protein product (nmol) | Before periodontal treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Monocyte chemoattractant protein-1(pg) | Before periodontal treatment | |
| The probing depth (mm), clinical attachment level (mm), plaque index scores (0-3) and gingival index scores (0-3) | Before periodontal treatment |
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Inclusion Criteria:
Exclusion Criteria:
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25 participants with chronic periodontitis, 25 participants with gingivitis and 25 periodontally healthy subjects are included.
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| ID | Term |
|---|---|
| D007249 | Inflammation |
| D010510 | Periodontal Diseases |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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