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| ID | Type | Description | Link |
|---|---|---|---|
| 2011-A01657-34 | Other Identifier | Agence Nationale de Sécurité des Médicaments |
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Suicidal behavior (SB) is a public health problem. The clinical model currently admitted to the understanding of SB is a stress vulnerability model, but so far, all scientific works has no clinical application. The management of psychiatric patients, including depressed subjects, faces the inability to detect those with a high risk of SB. Many studies have shown a link between low cholesterol and SB. A study has recently proposed a total cholesterol threshold below which the risk of suicide could be increased. However, a prospective study is needed to assess the predictive nature of such an indicator.
Investigators propose to assess, within a cohort of patients, the predictive value of a total cholesterol threshold in the occurrence of SB.
555 inpatients suffering from a current Major depressive disorder (MDD), hospitalized in the Department of Emergency Psychiatry and Post Acute Care will be recruited.
Each patient will attend a total of 5 visits during a follow-up period of 18 months (visits at 1, 3, 6, 12, and 18 months)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Major depressive episode | Other | Depressive patients will be assessed by interview (psychiatrists), questionnaires and blood sampling, as the inpatients's routine care |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| patient's routine care | Other | Interview by psychiatrists, questionnaires, blood analysis |
|
| Measure | Description | Time Frame |
|---|---|---|
| frequency of suicide attempts | frequency of suicide attempts during the 18months follow-up, according to the total cholesterol threshold at baseline. The biological sampling is carried out after 12 hours of fasting. | at 18 month |
| Measure | Description | Time Frame |
|---|---|---|
| number of past SB | Studying the relation between the number of past SB (assessed by the Columbia Suicide History Form) and the occurrence of new SB during the 18 months follow-up | at 18 month |
| moral pain |
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Inclusion criteria:
Exclusion criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Montpelleir University Hospital | Montpellier | 34295 | France |
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| ID | Term |
|---|---|
| D003863 | Depression |
| ID | Term |
|---|---|
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
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Studying the relation between moral pain (assessed by Likert scale from 0 to 10) at baseline and the occurrence of new SB during the 18 months follow-up
| at 18 month |
| physical pain | Studying the relation between physical pain (assessed Likert scale from 0 to 10) at baseline and the occurrence of new SB during the 18 months follow-up | at 18 month |
| suicidal ideation | Studying the relation between suicidal ideation (assessed by the Columbia Suicide Severity Rating Scale, the Scale of Suicidal Ideation) and the occurrence of new SB during the 18 months follow-up | at 18 month |
| depression (Quick Inventory of Depressive Symptomatology) | Studying the relation between score to the Quick Inventory of Depressive Symptomatology and the occurrence of new SB during the 18 months follow-up | at 18 month |
| history of childhood abuse | Studying the relation between an history of childhood abuse (assessed by the Childhood Trauma Questionnaire) and the occurrence of new SB during the 18 months follow-up | at 18 month |
| National Adult Reading Test score | Studying the relation between NART score (assessment of intellectual level) and the occurrence of new SB during the 18 months follow-up | at 18 month |
| scores to California Verbal Learning Test | Studying the relation between scores to California Verbal Learning Test (assessment of verbal memory) and the occurrence of SB during the 18 months follow-up | at 18 month |
| scores to Iowa Gambling Task Time frame: 18 months | Studying the relation between scores to the Iowa Gambling Task (assessment of decision making) and the occurrence of new SB during the 18 months follow-up | at 18 month |
| score to the brixton test | Studying the relation between score to the brixton test (assessment of mental flexibility) and the occurrence of SB during the 18 months follow-up | at 18 month |
| scores to verbal fluency | Studying the relation between scores to verbal fluency and the occurrence of SB during the 18 months follow-up | at 18 month |
| scores to Reversal Learning Task | Studying the relation between scores to Reversal learning task (assessment of decision making) and the occurrence of new SB during the 18 months follow-up | at 18 month |
| scores to the Attentional Stroop test | Studying the relation between scores to Attentional Stroop test and the occurrence of new SB during the 18 months follow-up | at 18 month |
| relation between inflammatory markers and the occurrence of SB | Studying the relation between inflammatory markers at baseline and the occurrence of new SB during the 18 months follow- | at 18 month |
| relation between thyroid function and the occurrence of SB | Studying the relation between thyroid function at baseline and the occurrence of new SB during the 18 months follow-up | at 18 month |
| relation between lipid profile and the occurrence of SB | Studying the relation between lipid profile at baseline and the occurrence of new SB during the 18 months follow-up | at 18 month |
| relation between pharmacological assays and the occurrence of SB | Studying the relation between pharmacological assays at baseline and the occurrence of new SB during the 18 months follow-up | at 18 month |
| relation between the characteristic of the mood depressive disorder (unipolar or bipolar depression) and the predictive or vulnerability factors of SB | Studying the potential specificity of predictive or vulnerability factors of SB depending on whether the diagnosis is unipolar or bipolar depression | at 18 month |
| the characteristic of past SB | Studying the relation between the number and the lethality of past SB (assessed by the Columbia Suicide History Form, the Risk Rescue Rating Scale, the Suicidal Intent Scale ) and the response to antidepressant treatment during the 18 months follow-up | at 18 month |
| moral pain | Studying the relation between moral pain (assessed by Likert scale from 0 to 10) at baseline and the response to antidepressant treatment during the 18 months follow-up | at 18 month |
| physical pain | Studying the relation between physical pain (assessed by Likert scale from 0 to 10) at baseline and the response to antidepressant treatment during the 18 months follow-up | at 18 month |
| suicidal ideation | Studying the relation between suicidal ideation (assessed by the Columbia Suicide Severity Rating Scale, the Scale of Suicidal Ideation) and the response to antidepressant treatment during the 18 months follow-up | at 18 month |
| depression level (Inventory of Depressive Symptomatology) | Studying the relation between score to the Inventory Of Depressive Symptomatology and the response to antidepressant treatment during the 18 months follow-up | at 18 month |
| history of childhood abuse | Studying the relation between an history of childhood abuse (assessed by the childhood trauma questionnaire) and the response to antidepressant treatment during the 18 months follow-up | at 18 month |
| National Adult Reading Test score ( NART) | Studying the relation between NART score (assessment of intellectual level ) and the response to antidepressant treatment during the 18 months follow-up | at 18 month |
| scores to California Verbal Learning Test | Studying the relation between scores to California Verbal Learning Test (assessment of verbal memory) and the response to antidepressant treatment during the 18 months follow-up | at 18 month |
| scores to Iowa Gambling Task | Studying the relation between scores to Iowa Gambling Task (assessment of decision making) and the response to antidepressant treatment during the 18 months follow-up | at 18 month |
| score to the brixton test | Studying the relation between score to the brixton test (assessment of mental flexibility) and the response to antidepressant treatment during the 18 months follow-up | at 18 month |
| verbal fluency | Studying the relation between score to verbal fluency and the response to antidepressant treatment during the 18 months follow-up | at 18 month |
| scores to Reversal Learning Task | Studying the relation between scores to Reversal learning task (assessment of decision making) and the response to antidepressant treatment during the 18 months follow-up | at 18 month |
| scores to the Attentional Stroop test | Studying the relation between scores to Attentional Stroop test and the response to antidepressant treatment during the 18 months follow-up | at 18 month |
| relation between inflammatory markers and the response to antidepressant treatment | Studying the relation between inflammatory markers at baseline and the response to antidepressant treatment during the 18 months follow-up | at 18 month |
| relation between thyroid function and the response to antidepressant treatment | Studying the relation between thyroid function at baseline and the response to antidepressant treatment during the 18 months follow-up | at 18 month |
| relation between lipid profile and the response to antidepressant treatment | Studying the relation between lipid profile at baseline and the response to antidepressant treatment during the 18 months follow-up | at 18 month |
| relation between pharmacological assays and the response to antidepressant treatment | Studying the relation between pharmacological assays at baseline and t the response to antidepressant treatment during the 18 months follow-up | at 18 month |
| lethality of past SB | Studying the relation between the lethality of past SB (assessed by the Columbia Suicide History Form) and the occurrence of new SB during the 18 months follow-up | at 18 month |
| Depression (Inventory of Depressive Symptomatology) | Studying the relation between score to the Inventory Of Depressive Symptomatology and the occurrence of new SB during the 18 months follow-up | at 18 month |
| Depression (Beck Depression Inventory) | Studying the relation between score to the Beck Depression Inventory and the occurrence of new SB during the 18 months follow-up | at 18 month |
| depression level (Beck depression Inventory) | Studying the relation between score to the Beck depression Inventory and the response to antidepressant treatment during the 18 months follow-up | at 18 month |
| depression level (Quick Inventory of Depressive Symptomatology) | Studying the relation between score to the Quick Inventory of Depressive Symptomatology and the response to antidepressant treatment during the 18 months follow-up | at 18 month |