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Respiratory Viral Infections (RVI) are particularly frequent in young children. Old data mention the deleterious role of some viruses such as the Respiratory Syncytial Virus in young children with cystic fibrosis (CF). However, recent epidemiological data on RVI in CF children are rare and the impact of most frequent viruses such as human rhinoviruses is usually not correctly evaluated.
The aim of this study is to assess the frequency of lower and upper RVI during a 1 year follow-up in CF infants and to evaluate the impact of RVI at a clinical, microbiological and therapeutic level.
Our hypothesis is that frequent and/or clinically severe RVIs have the worst impact in the short term and without any particular link with a specific virus as previously described.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| cystic fibrosis infants | Other | 1 year follow-up in CF infants |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Physical assessment | Other | 1 year follow-up in CF infants with clinical, microbiological and therapeutic assessments |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of Respiratory Viral Infection | up to 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Identification of respiratory viruses in throat-swabs | A panel of 10 viruses will be tested using polymerase chain reaction (PCR) and RT-PCR technology. | up to 12 months |
| Number of antibiotics treatments (oral or IV) |
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Inclusion Criteria:
- infant <24 months with cystic fibrosis
Exclusion Criteria:
- patient >24 months
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| Name | Affiliation | Role |
|---|---|---|
| Stéphanie VRIELYNCK, MD | Cystic Fibrosis Pediatric Reference Centrer, Hospices Civils de Lyon, 69677 Bron Cedex, France | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cystic Fibrosis Pediatric Reference Centrer, Hospices Civils de Lyon | Bron | 69677 | France |
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| ID | Term |
|---|---|
| D003550 | Cystic Fibrosis |
| D014777 | Virus Diseases |
| ID | Term |
|---|---|
| D010182 | Pancreatic Diseases |
| D004066 | Digestive System Diseases |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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| ID | Term |
|---|---|
| D012149 | Restraint, Physical |
| ID | Term |
|---|---|
| D032763 | Behavior Control |
| D013812 | Therapeutics |
| D007103 | Immobilization |
| D008919 | Investigative Techniques |
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| up to 12 months |
| Number of bronchodilator administrations | up to 12 months |
| Number of corticosteroids administrations | up to 12 months |
| Number of hospitalization or hospital admission due to upper or lower RVI | up to 12 months |
| Identification of bacterial flora in throat-swabs | up to 12 months |
| D030342 |
| Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D007232 | Infant, Newborn, Diseases |
| D007239 | Infections |