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This study investigates the effects of dexmedetomidine and esmolol given intravenously before intubation on sympathetic response caused by intubation itself. Half the patients will recevice dexmedetomidine and the other half will receive dexmedetomidine. Ischemia modified albumine levels will be measured
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| dexmedetomidine | Experimental | 0.5 mcg/kg dexmedetomidine in 20 ml normal saline will be infused in 5 minutes before intubation |
|
| Esmolol | Experimental | 0.5 mg/kg esmolol in 20 ml normal saline will be infused in 5 minutes before intubation |
|
| Placebo | Placebo Comparator | 20 ml normal saline infused in 5 minutes before intubation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexmedetomidine | Drug |
| ||
| Esmolol |
| Measure | Description | Time Frame |
|---|---|---|
| ischemia modified albumine | ischemia modified albumine levels will be measured as a response to intubation | 10 minutes after endotracheal intubation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Perihan Ekmekçi, Ass Prof | Contact | +903122044000 | 4099 | erdogduperi@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ufuk University Hospital | Recruiting | Ankara | 06520 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25886340 | Result | Yallapragada SV, Vidadala KS, Vemuri NN, Shaik MS. Comparison of the efficacy of dexmedetomidine with that of esmolol in attenuating laryngoscopic and intubation response after rapid sequence induction. Anesth Essays Res. 2014 Sep-Dec;8(3):383-7. doi: 10.4103/0259-1162.143154. |
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| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| C036604 | esmolol |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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|
| Placebo | Drug | normal saline |
|