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| ID | Type | Description | Link |
|---|---|---|---|
| 2012-A01344-39 | Other Identifier | ID-RCB number, ANSM |
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| Name | Class |
|---|---|
| Seventh Framework Programme | OTHER |
| University of Lausanne Hospitals | OTHER |
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This is a prospective case-control physiopathological study, which main objective is to determine the genetic host factors predisposing to candidemia. Secondary objectives are to develop new diagnosis tools using the biological collection, to describe and update epidemiology, to analyse the influence of genetic polymorphisms on prognosis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Candidemia patients | These patients are included in the study after the reception of a positive blood culture for Candida sp. |
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| Control patients | These patients are matched on case patients on the following criteria:
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Analysis of genetic polymorphisms | Genetic | An analysis of the SNPs (single nucleotide polymorphism) of 25 candidate genes will be performed. This analysis will be completed by a genome wide association study. |
| Measure | Description | Time Frame |
|---|---|---|
| Frequency of the polymorphisms between the groups | In the 48-72 hours following the positive blood culture |
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Inclusion Criteria:
Exclusion Criteria:
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Hospitalized patients exhibiting a positive blood culture with isolation of Candida sp.
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| Name | Affiliation | Role |
|---|---|---|
| Julien Poissy, MD, PhD | University Hospital, Lille | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital Salengro, Intensive care departement, CHRU | Lille | France |
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| ID | Term |
|---|---|
| D058365 | Candidiasis, Invasive |
| D058387 | Candidemia |
| D020022 | Genetic Predisposition to Disease |
| ID | Term |
|---|---|
| D002177 | Candidiasis |
| D009181 | Mycoses |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
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20 mL of blood samples are collected at inclusion. 10 mL on EDTA tubes for the genetic analysis, and 1 mL on dry tube for biomarkers development.
Paxgen tubes will be collected in a sample of patients for a transcriptomic study.
| D000072742 |
| Invasive Fungal Infections |
| D016469 | Fungemia |
| D018805 | Sepsis |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D004198 | Disease Susceptibility |
| D020969 | Disease Attributes |