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The purpose of this study is to use a new method to differentiate mnesic abilities of early alzheimer patients and patients with a depressive disorder.
This method is based on the recording of cerebral activity while patients listen to familiar, unfamiliar and newly-learned music.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Alzheimer patients | Experimental | Cerebral measurements from high-density electroencephalography are recorded in Alzheimer patients. The same protocol is applied in the 3 arms |
|
| patients with a depressive disorder | Experimental | Cerebral measurements from high-density electroencephalography are recorded in patients with a depressive disorder. The same protocol is applied in the 3 arms |
|
| Healthy controls | Active Comparator | Cerebral measurements from high-density electroencephalography are recorded in healthy controls |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| high-density electroencephalography | Device | Musical stimulation during electroencephalography recording |
|
| Measure | Description | Time Frame |
|---|---|---|
| Amplitude of event-related potentials | Measurements of the amplitude of event-related potentials with electroencephalography at day one for familiar and unfamiliar songs and after 2 weeks for newly learned songs | day 1 for familiar and unfamiliar songs and day 14 for newly learned songs |
| Measure | Description | Time Frame |
|---|---|---|
| Spectral power | Measurements of the spectral power with electroencephalography at day one for familiar and unfamiliar songs and after 2 weeks for newly learned songs | day 1 for familiar and unfamiliar songs and day 14 for newly learned songs |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Damien Gabriel, PhD | Contact | 0033381219148 | dgabriel@chu-besancon.fr | |
| Magali Nicolier, PhD | Contact | 0033381219007 | mnicolier@chu-besancon.fr |
| Name | Affiliation | Role |
|---|---|---|
| Pierre Vandel, MD, PhD | Service de psychiatrie | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHRU Besançon | Recruiting | Besançon | Franche-Comte | 25000 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27131744 | Background | Gabriel D, Wong TC, Nicolier M, Giustiniani J, Mignot C, Noiret N, Monnin J, Magnin E, Pazart L, Moulin T, Haffen E, Vandel P. Don't forget the lyrics! Spatiotemporal dynamics of neural mechanisms spontaneously evoked by gaps of silence in familiar and newly learned songs. Neurobiol Learn Mem. 2016 Jul;132:18-28. doi: 10.1016/j.nlm.2016.04.011. Epub 2016 Apr 27. |
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| ID | Term |
|---|---|
| D000544 | Alzheimer Disease |
| D003863 | Depression |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| D024801 |
| Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |