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Aim to assess feasibility achieved, larger project starting earlier than anticipated
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| Name | Class |
|---|---|
| University of Gondar | OTHER |
| Addis Ababa University | OTHER |
| Metema District Hospital, Metema, Ethiopia | UNKNOWN |
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To collect pilot data on the prevalence and incidence of asymptomatic Leishmania donovani infection in HIV infected individuals in a visceral leishmaniasis (VL)-HIV endemic region to inform the feasibility of a larger study exploring a screen and treat strategy for VL in HIV co-infected individuals in East-Africa (Ethiopia).
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| Measure | Description | Time Frame |
|---|---|---|
| The proportion of individuals with L.donovani asymptomatic infection at baseline in HIV coinfected adults enrolled in HIV care in a VL-HIV endemic region in North-West Ethiopia. | Proportion of individuals with asymptomatic infection, defined as positivity on any of the leishmanial markers (PCR, urine antigen or serology) | End of study (2 years) |
| Measure | Description | Time Frame |
|---|---|---|
| The proportion of individuals with asymptomatic infection during follow-up in HIV coinfected adults enrolled in HIV care in a VL-HIV endemic region in North-West Ethiopia | Proportion of individuals with asymptomatic infection during follow-up, defined as positivity on any of the leishmanial markers (PCR, urine antigen or serology) amongst those without asymptomatic infection during the cross-sectional evaluation. |
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Inclusion Criteria:
Exclusion Criteria:
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Adult individuals enrolled in HIV care in Metema hospital
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Metema District Hospital | Metemma | Ethiopia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31593563 | Derived | van Griensven J, van Henten S, Mengesha B, Kassa M, Adem E, Endris Seid M, Abdellati S, Asefa W, Simegn T, Debasu D, Bogale T, Gedamu Y, Van Den Bossche D, Adriaensen W, Van der Auwera G, Cnops L, Vogt F, Diro E. Longitudinal evaluation of asymptomatic Leishmania infection in HIV-infected individuals in North-West Ethiopia: A pilot study. PLoS Negl Trop Dis. 2019 Oct 8;13(10):e0007765. doi: 10.1371/journal.pntd.0007765. eCollection 2019 Oct. |
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| ID | Term |
|---|---|
| D007898 | Leishmaniasis, Visceral |
| ID | Term |
|---|---|
| D007896 | Leishmaniasis |
| D056986 | Euglenozoa Infections |
| D011528 | Protozoan Infections |
| D010272 | Parasitic Diseases |
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Serum Plasma Whole blood Urine Stool
| End of study (2 years) |
| Proportions of individuals with a positive test on a specific leishmanial marker to describe the pattern of asymptomatic infection. | End of study (2 years) |
| Proportion of asymptomatic infected patients in clinical determinant groups. | Clinical determinant groups are constructed with key clinical characteristics and history | End of study (2 years) |
| Total proportion of baseline asymptomatic infected patients, with positive infection status at 3, 6, 9 and 12 months follow-up. | 3, 6, 9 and 12 months of follow-up |
| Proportion of baseline asymptomatic infected patients, with positive infection status for each baseline leishmanial marker at 3, 6, 9 and 12 months | 3, 6, 9 and 12 months of follow-up |
| Proportion of individuals developing VL within the following year (= One-year risk of VL) | VL will be diagnosed as per national guidelines. | End of study (2 years) |
| D007239 |
| Infections |
| D000079426 | Vector Borne Diseases |