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| Name | Class |
|---|---|
| Augustinus Fonden | OTHER |
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The purpose of this study is to evaluate self-reported symptoms as a proxy for acute organophosphate poisoning by examining self-reported acute organophosphate poisoning symptoms and PchE activity in response to occupational acute organophosphate exposure among farmers in Nepal.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A | Other | Initial spray session: organophosphate. Crossover spray session: placebo |
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| Group B | Other | Initial spray session: placebo. Crossover spray session: organophosphate |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Organophosphate | Other | Chlorpyrifos 50% plus cypermethrin 5%, WHO Class II: Moderately hazardous |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in self-reported acute organophosphate poisoning symptoms from baseline to follow up | Obtained using a structured questionnaire interview. The definition of symptoms was based on WHO's standardized list of clinical presentations of acute organophosphate poisoning. | Obtained just before (baseline) and 30 minutes after (baseline) each spray session |
| Change in Plasma Cholinesterase (PchE) activity from baseline to follow up | PchE activity was measured with a blood test using a Test-mate Che Cholinesterase System (Model 400) with a PchE Plasma Cholinesterase Assay Kit (Model 470). | Obtained just before (baseline) and 30 minutes after (baseline) each spray session |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Dea H. Kofod, MB | Department of Occupational and Environmental Medicine, Bispebjerg Frederiksberg Hospital, University of Copenhagen | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27964728 | Derived | Kofod DH, Jors E, Varma A, Bhatta S, Thomsen JF. The use of self-reported symptoms as a proxy for acute organophosphate poisoning after exposure to chlorpyrifos 50% plus cypermethrin 5% among Nepali farmers: a randomized, double-blind, placebo-controlled, crossover study. Environ Health. 2016 Dec 13;15(1):122. doi: 10.1186/s12940-016-0205-1. |
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| ID | Term |
|---|---|
| D062025 | Organophosphate Poisoning |
| ID | Term |
|---|---|
| D011041 | Poisoning |
| D064419 | Chemically-Induced Disorders |
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| ID | Term |
|---|---|
| D010755 | Organophosphates |
| D061046 | Biological Control Agents |
| ID | Term |
|---|---|
| D009943 | Organophosphorus Compounds |
| D009930 | Organic Chemicals |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |
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| Placebo | Other | Multineem, WHO Class U: Unlikely to present acute hazard in normal use |
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