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The purpose of this study is to evaluate the effect of L-Dopa on the progression of retinitis pigmentosa.
Retinitis pigmentosa is a group of progressive hereditary diseases that diffusely affects the functioning of photoreceptors and the pigment epithelium. It may be speculated that a protective effect on the pigment epithelium, as it is supposed for L-Dopa, can slow the progression of the disease or even lead to an, at least transient, improvement of visual functions. To evaluate the effect of L-Dopa on retinitis pigmentosa progression, visual acuity, electroretinogram and visual field will be preformed regularly.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Treatment | Experimental | This is a single armed study. All patients included will receive treatment. Control will happen with data from the same patients before they received treatment. patients will receive sinemet 200/50 1/2 tablet (levodopa-carbidopa 100/25) b.i.d for two days and then will be increased to t.i.d. for 6 months. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| levodopa-carbidopa | Drug | sinemet 200/50 1/2 tablet b.i.d. for 2 days and then t.i.d for 6 months |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in Electroretinogram | the electric response to light stimuli of the retina, in millivolt, will be measured. The electroretinogram shows a-waves (elicit information about the function of the photoreceptors) and b-waves (elicit information about other neurosensory structure of the retina) | Baseline, 1 year, 2 years, 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Visual Acuity | Visual acuity will be measured using Snellen chart | Baseline, 6 months, 1 year, 2 years, 5 years |
| Change in Visual Field | Using 24-2 Humphrey Visual Field Analyzer, the progress in visual field defect will be measured, comparing mean deviation (dB) and pattern standard deviation (dB) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Elias F. Jarade, MD | Contact | +9613549297 | ejarade@yahoo.com | |
| Beirut Eye Specialist Hospital | Contact | +961 1 423111 | 0 | info@besh.com.lb |
| Name | Affiliation | Role |
|---|---|---|
| Elias F. Jarade, MD | Beirut Eye Specialist Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beirut Eye Specialist Hospital | Recruiting | Beirut | 116-5311 | Lebanon |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26524704 | Background | Brilliant MH, Vaziri K, Connor TB Jr, Schwartz SG, Carroll JJ, McCarty CA, Schrodi SJ, Hebbring SJ, Kishor KS, Flynn HW Jr, Moshfeghi AA, Moshfeghi DM, Fini ME, McKay BS. Mining Retrospective Data for Virtual Prospective Drug Repurposing: L-DOPA and Age-related Macular Degeneration. Am J Med. 2016 Mar;129(3):292-8. doi: 10.1016/j.amjmed.2015.10.015. Epub 2015 Oct 30. |
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Individual participant date will not be shared at the moment being, since it is not of value unless it is thoroughly analysed.
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| ID | Term |
|---|---|
| D012174 | Retinitis Pigmentosa |
| ID | Term |
|---|---|
| D015785 | Eye Diseases, Hereditary |
| D005128 | Eye Diseases |
| D058499 | Retinal Dystrophies |
| D012162 | Retinal Degeneration |
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| ID | Term |
|---|---|
| C009265 | carbidopa, levodopa drug combination |
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| Baseline, 1 year, 2 years, 5 years |
| D012164 |
| Retinal Diseases |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |