Study of Degenerescence CSF Hallmarks in Older Bipolar Patients

Study of Degenerescence CSF Hallmarks in Older Bipolar Patients

Analysis of 4 CSF Alzheimer's disease biomarkers (total and phosphorylated tau protein, Aß40 and Aß1-42) and morphological brain MRI in older patients (>60 year's old) with bipolar disorder, after an evaluation of their cognitive functions.

Comparison between two groups of patients : patients with cognitive disorders and patients without cognitive disorders.

The objective is to describe and compare the profile of those biomarkers in those two populations.

Describe the profile of the 4 neurodegeneration's biomarkers of Alzheimer's disease dosed in the cerebrospinal fluid (Total Tau proteins, phosphorylated, Aß40 and Aß1-42) for old subjects suffering from bipolar disorder with or without cognitive impairment.

Inclusion Criteria:

• male or female between 60 and 80

• french-speaking, reading and writing patient

• affiliation to the French Social Security

• written informed consent obtained from the patient

• agree to undergo a lumbar puncture

• easy accessibility for the lumbar puncture

• Mini Mental State Examination (MMSE) > 20

• bipolar patients :

  • type I or II
  • state of euthymia for at least 4 weeks
  • stable psychotropic drug treatment for at least 8 weeks
  • no electroconvulsive therapy during the 6 months before inclusion

• distribution in the "with cognitive disorder" or "without cognitive disorder" group is function of the result of the neuropsychological evaluation

Non-inclusion Criteria :

• severe visual or auditory disorder
• advanced lumbar osteoarthritis
• history of severe head injury, neurological disorders, diagnosed dementia
• addiction weaned for less than 12 months
• forced hospitalization in psychiatry
• MRI contraindications
• LP contraindications

Exclusion Criteria:

- at least one of the outcome measures can't be performed :

• MRI
• LP : anticoagulation, bad accessibility