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SPECTA is a quality assured platform for collecting clinicopathologically annotated biological material, imaging data, operative images, environmental assessment, questionnaires as well as patient-reported outcomes from cancer patients to support biospecimen-based translational research and clinical cancer research, including biomarker discovery to improve the understanding of tumor biology and cancer patients care.
Patients are recruited in the platform for the research purpose of 5 downstream projects. For more information, please have a look at the "Groups and cohorts" section.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| RP-1828 IMMUcan (CLOSED for recruitment since August 2024) | The goal is to generate broad molecular and cellular profiling data of the tumour and its microenvironment from cancer patients integrated with clinical data, to understand how the immune system and tumours interact, and the impact of current therapeutic interventions. Tumor types: Thorax, Head and Neck, Breast, Gastrointestinal, Genito Urinary |
| |
| RP-1759 AYA/TYA (CLOSED for recruitment since December 2021) | The pilot study will be focusing on young adults (12 to 29 years old) with rare cancer to understand better the biology of the tumor in this specific population, and compare it to children and adults with similar disease, as well as to improve the inclusion of young adults into clinical trials. Tumor type: CNS |
| |
| RP-1843 Arcagen (CLOSED for recruitment since November 2022) | This is a collaborative project between EORTC and EURACAN to perform molecular characterisation of rare cancers patients, using Foundation Medicine tests. The goal of this project is to get a better understanding of the genomic landscape of rare cancers and potentially help define possibilities for targeted treatments/clinical trials for this population. Tumor types: all 10 EURACAN domains |
| |
| RP-1920 BioRadon | The primary objective is to assess the correlation between the molecular profiles of NSCLC patients and indoor radon concentration, measured with an alpha-particle detector (a standardized and validated way of measuring indoor radon). Tumor type: Thorax |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| RP-1828 IMMUcan | Genetic | WES, lcWGS and RNAseq, multiplex IF and IMC |
|
| Measure | Description | Time Frame |
|---|---|---|
| To establish a quality assured platform to improve the understanding of tumor biology and cancer patients care | material (including imaging data) as well as patient-reported outcomes from patients with cancer diagnosis to support biospecimen-based translational research and biomarker discovery to improve the understanding of tumor biology and cancer patients care. | 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| To perform biospecimen and data based high quality research aiming to better understand the biology of cancer, and/or how it is currently managed and/or how to better diagnose and treat it in the future; | 5 years | |
| To investigate the molecular pathways related to the development of specific tumors from a biological point of view; |
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Patients with pathologically confirmed selected tumor types.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| EORTC HQ | Contact | +32 2 774 1611 | specta@eortc.org |
| Name | Affiliation | Role |
|---|---|---|
| Benjamin Besse, Pr. | European Organisation for Research and Treatment of Cancer - EORTC | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical University Vienna - General Hospital AKH | Recruiting | Vienna | 1090 | Austria | ||
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FFPE tissue sample; Blood sample; Fresh bone marrow sample (in case of hematological malignancies)
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| 2148 MRD | The main objective of the 2148 Minimal Residual Disease Assessment project is to assess the potential of circulating tumor DNA (ctDNA) as a surrogate marker of recurrence by studying its positive predictive value (PPV). This will help determine how accurately ctDNA can predict cancer recurrence. Tumour types: Head and Neck, Melanoma |
|
| RP-1759 AYA/TYA | Genetic | WES, RNAseq and EPIC array |
|
| RP-1843 Arcagen | Genetic | NGS panel |
|
| RP-1920 BioRadon | Genetic | NGS panel |
|
| 2148 MRD | Genetic | ctDNA detection and WES |
|
| 5 years |
| To investigate the effect of cancer treatment on the tumor, microenvironment and patients globally; | 5 years |
| To collect large series of homogeneous clinical data to analyse the disease course and treatment performed; | 5 years |
| To investigate the prevalence and validate the prognostic or predictive value of novel biomarkers in cancers; | 5 years |
| To perform biospecimen and data based high quality research aiming to facilitate the discovery of new test for tumor biomarkers or facilitate the establishment of validated tests for tumor biomarkers; | 5 years |
| To identify patients with molecular alterations in their tumor that can be matched to biomarker-driven clinical trials, to facilitate enrollment of cancer patients in biomarker-driven clinical trials. | 5 years |
| Onze Lieve Vrouw Ziekenhuis |
| Recruiting |
| Aalst |
| 9300 |
| Belgium |
| ZAS Middelheim | Recruiting | Antwerp | 2020 | Belgium |
| Hopitaux Universitaires - Institut Jules Bordet | Recruiting | Brussels | 1000 | Belgium |
| Universitair Ziekenhuis Brussel | Recruiting | Brussels | 1000 | Belgium |
| Cliniques Universitaires Saint-Luc | Recruiting | Brussels | 1200 | Belgium |
| Universitair Ziekenhuis Gent | Recruiting | Ghent | 9000 | Belgium |
| Pole Hospitalier Jolimont - Hopital Jolimont | Recruiting | Haine-Saint-Paul | 7100 | Belgium |
| U.Z. Leuven - Campus Gasthuisberg | Recruiting | Leuven | 3000 | Belgium |
| C.H.U. Sart-Tilman | Recruiting | Liège | 4000 | Belgium |
| Centre Hospitalier Regional De La Citadelle | Recruiting | Liège | 4000 | Belgium |
| CHU Site Sainte-Elisabeth-UCL Namur | Recruiting | Namur | 5000 | Belgium |
| AZ Turnhout - Campus Sint Elisabeth | Recruiting | Turnhout | 2300 | Belgium |
| CHU Mont Godinne - UCL Namur | Recruiting | Yvoir | 5530 | Belgium |
| University Hospital Centre Zagreb | Active, not recruiting | Zagreb | 10000 | Croatia |
| Bank Of Cyprus Oncology Centre | Recruiting | Stróvolos | 2006 | Cyprus |
| University Hospital Motol | Recruiting | Prague | 150 06 | Czechia |
| North Estonia Medical Centre - Mustamäe unit | Recruiting | Tallinn | 13419 | Estonia |
| Centre Hospitalier Avignon | Recruiting | Avignon | 84902 | France |
| CHRU de Besancon - Hopital Jean Minjoz | Recruiting | Besançon | 25030 | France |
| Centre de Radiotherapie Pierre Curie | Recruiting | Beuvry | 62660 | France |
| CHU de Bordeaux - Groupe Hospitalier Saint-Andre - Hopital Saint-Andre | Recruiting | Bordeaux | 33075 | France |
| Institut Bergonie | Recruiting | Bordeaux | 33076 | France |
| Centre Hospitalier - Boulogne Sur Mer | Recruiting | Boulogne-sur-Mer | 62321 | France |
| CHU de Lyon - Hopital Louis Pradel | Recruiting | Bron | 69500 | France |
| CHU Lyon - Hopital neurologique Pierre Wertheimer | Recruiting | Bron | 69677 Cedex | France |
| Centre Francois Baclesse | Recruiting | Caen | 14076 | France |
| Centre Hopitalier Intercommunal De Creteil | Recruiting | Créteil | 94010 | France |
| Centre Georges-Francois-Leclerc | Recruiting | Dijon | 21079 | France |
| CHU de Grenoble - La Tronche - Hôpital A. Michallon | Recruiting | Grenoble | 38043 | France |
| Centre Hospitalier Departemental Vendee | Recruiting | La Roche-sur-Yon | 85925 | France |
| Centre Oscar Lambret | Recruiting | Lille | 59000 | France |
| CHRU de Lille | Recruiting | Lille | 59037 Cedex | France |
| CHU de Lyon - Hopital Edouard Herriot | Recruiting | Lyon | 69003 | France |
| Centre Léon Berard | Recruiting | Lyon | 69008 | France |
| CHU de Lyon - Hopital Lyon Sud | Recruiting | Lyon | 69495 | France |
| Assistance Publique - Hopitaux de Marseille - Hopital Nord | Recruiting | Marseille | 13015 | France |
| Centre Hospitalier D'Annecy Genevois | Recruiting | Metz-Tessy | 74370 | France |
| CHU Montpellier-Hopital Arnaud De Villeneuve | Recruiting | Montpellier | 34295 CEDEX 5 | France |
| Institut du Cancer de Montpellier | Recruiting | Montpellier | 34298 | France |
| Centre Hospitalier Des Pays De Morlaix | Recruiting | Morlaix | 29600 | France |
| Centre d'Oncologie de Gentilly | Recruiting | Nancy | 54100 | France |
| CHU de Nice - Hopital De L'Archet | Recruiting | Nice | 06200 | France |
| Assitance Publique - Hopitaux de Paris - Hopital Saint-Louis | Recruiting | Paris | 75010 | France |
| Assistance Publique - Hopitaux de Paris - Hopital Saint Antoine | Recruiting | Paris | 75012 | France |
| Assistance Publique - Hopitaux de Paris - La Pitie Salpetriere | Recruiting | Paris | 75013 | France |
| Institut Curie- Hopital de Paris | Recruiting | Paris | 75248 CEDEX 05 | France |
| Groupe Hospitalier Paris Saint-Joseph - Hopital Saint Joseph | Recruiting | Paris | 75674 | France |
| Centre Eugene Marquis | Recruiting | Rennes | 35042 | France |
| Institut de Cancerologie de l'Ouest (ICO) - Centre Rene Gauducheau | Recruiting | Saint-Herblain | 44805 | France |
| Clinique Mutualiste de l'Estuaire - Centre d'oncologie | Recruiting | Saint-Nazaire | 44600 | France |
| Institut de Cancerologie de la Loire Lucien Neuwirth | Recruiting | Saint-Priest-en-Jarez | 42270 | France |
| Institut de Cancerologie Strasbourg Europe (formar Paul Strauss) | Recruiting | Strasbourg | 67200 | France |
| CHU Toulouse - Hopital Larrey | Recruiting | Toulouse | 31059 | France |
| Gustave Roussy | Recruiting | Villejuif | 94805 | France |
| Charite - Universitaetsmedizin Berlin - Campus Virchow-Klinikum | Recruiting | Berlin | 13353 | Germany |
| Universitaetsklinikum Carl Gustav Carus | Recruiting | Dresden | 01307 | Germany |
| Universitaetsklinikum Greifswald der Ernst Morizt Arndt Univ. Greifswald AoR | Recruiting | Greifswald | 17475 | Germany |
| Universitaetsklinikum Jena | Recruiting | Jena | 07447 | Germany |
| Onkologie UnterEms, Leer-Papenburg-Emden | Recruiting | Leer | 26789 | Germany |
| NIMTS - Veterans Administration Hospital | Recruiting | Athens | 11521 | Greece |
| Athens University - Attikon University General Hospital | Recruiting | Athens | 12462 | Greece |
| Hygeia Hospital | Recruiting | Athens | 151 23 | Greece |
| Ioannina University Hospital | Active, not recruiting | Ioannina | 45500 | Greece |
| Ospedale Civile Santi Antonio e Biagio e Cesare Arrigo | Recruiting | Alessandria | 15100 | Italy |
| Alma Mater Studiorium Universita di Bologna - Loc. Ospedala Sant'Orsolo | Recruiting | Bologna | 40138 | Italy |
| Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia | Suspended | Brescia | 25123 | Italy |
| Azienda Istituti Ospitalieri di Cremona | Recruiting | Cremona | 26100 | Italy |
| IRCCS Azienda Ospedaliera Universitaria San Martino "IST" Istituto Nazionale per la Ricerca sul Cancro | Recruiting | Genova | 16132 | Italy |
| Azienda Unita Locale Socio-Sanitaria N. 9-Mater Salutis Hospital | Recruiting | Legnago | 37045 | Italy |
| IRCCS - Fondazione Istituto Nazionale dei Tumori | Recruiting | Milan | 20133 | Italy |
| IRCCS - Istituto Neurologico Carlo Besta | Recruiting | Milan | 20133 | Italy |
| Azienda Sanitaria Locale Napoli 1 Centro | Recruiting | Naples | 80147 | Italy |
| Universita Di Torino - Ospedale S. Luigi Gonzaga | Recruiting | Orbassano | 10043 | Italy |
| IRCCS - Istituto Oncologico Veneto | Recruiting | Padova | 35128 | Italy |
| Istituti Clinici Scientifici Maugeri | Recruiting | Pavia | 27100 | Italy |
| Regina Elena National Cancer Center | Recruiting | Roma | 00144 | Italy |
| Azienda Ospedaliera Città della Salute e della Scienza di Torino - Ospedale Molinette | Recruiting | Torino | 10126 | Italy |
| Azienda Ospedaliera Città della Salute e della Scienza di Torino - Ospedale San Giovanni - Dipartimento Neuroscienze | Recruiting | Torino | 10126 | Italy |
| Azienda Ospedaliera Città della Salute e della Scienza di Torino - Ospedale Sant'Anna | Suspended | Torino | 10126 | Italy |
| Lithuanian Oncology Center-Nat. Cancer Inst | Recruiting | Vilnius | 08660 | Lithuania |
| The Netherlands Cancer Institute-Antoni Van Leeuwenhoekziekenhuis | Recruiting | Amsterdam | 1066 CX | Netherlands |
| Amsterdam UMC - Locatie AMC | Recruiting | Amsterdam | 1105 AZ | Netherlands |
| University Medical Center Groningen | Recruiting | Groningen | 9713 GZ | Netherlands |
| Academisch Ziekenhuis Maastricht | Recruiting | Maastricht | 6202 AZ | Netherlands |
| Radboud University Medical Center Nijmegen | Recruiting | Nijmegen | 6525GA | Netherlands |
| Medical University Of Gdansk | Recruiting | Gdansk | 80 211 | Poland |
| Maria S. Curie Memorial Institute-Gliwice Branch | Recruiting | Gliwice | 44-101 | Poland |
| The Great Poland Cancer Centre | Recruiting | Poznan | 61 866 | Poland |
| Maria Sklodowska-Curie Memorial Cancer Centre | Active, not recruiting | Warsaw | Poland |
| Instituto Portugues De Oncologia - Centro De Coimbra | Recruiting | Coimbra | 3000-075 | Portugal |
| Instituto Portugues de Oncologia de Lisboa Francisco Gentil - EPE | Recruiting | Lisbon | 1099-023 CODEX | Portugal |
| Hospital CUF Tejo | Recruiting | Lisbon | 1350-352 | Portugal |
| Centro Hospitalar de Lisboa Ocidental- San Francisco Xavier Hospital | Recruiting | Lisbon | 1449-005 | Portugal |
| Hospital CUF Descobertas | Recruiting | Lisbon | 1998-018 | Portugal |
| Centro Hospitalar do Porto- Hospital de Santo Antonio | Recruiting | Porto | 4099-001 | Portugal |
| Instituto Portugues de Oncologia do Porto | Recruiting | Porto | 4200-162 | Portugal |
| Unidade Local de Saúde Gaia e Espinho | Recruiting | Vila Nova de Gaia | 4430 | Portugal |
| Medisprof Cancer Center srl | Recruiting | Cluj-Napoca | Cluj Napoca | 400058 | Romania |
| University Clinic Centre Serbia - Pulmonology clinic | Recruiting | Belgrade | 11000 | Serbia |
| University Clinical Center of Serbia - Clinic for ENT and MFH | Recruiting | Belgrade | 11000 | Serbia |
| University Clinic Golnik | Recruiting | Golnik | 4204 | Slovenia |
| University Medical Center Maribor | Recruiting | Maribor | 2000 | Slovenia |
| ICO L'Hospitalet - Hospital Duran i Reynals (Institut Catala D'Oncologia) | Recruiting | L'Hospitalet de Llobregat | Barcelona | 08908 | Spain |
| Vall d'Hebron Institut d'Oncologia | Recruiting | Barcelona | 08035 | Spain |
| Hospital Clinic Universitari de Barcelona | Recruiting | Barcelona | 08036 | Spain |
| Hospital De La Santa Creu I Sant Pau | Recruiting | Barcelona | 08041 | Spain |
| Hospital General Universitario De Elche | Active, not recruiting | Elche | 03203 | Spain |
| ICO Girona - Hospital Doctor Josep Trueta (Institut Catala D'Oncologia) | Recruiting | Girona | 17007 | Spain |
| ICO L'Hospitalet- Hospital Universitari de Bellvitge | Recruiting | L'Hospitalet de Llobregat | 08907 | Spain |
| Hospital Infantil Universitario Nino Jesus | Recruiting | Madrid | 28009 | Spain |
| Hospital Universitario Infanta Leonor | Recruiting | Madrid | 28031 | Spain |
| Hospital Universitario Ramon y Cajal | Recruiting | Madrid | 28034 | Spain |
| Hospital Universitario San Carlos | Recruiting | Madrid | 28040 | Spain |
| Hospital Universitario 12 de Octubre | Recruiting | Madrid | 28041 | Spain |
| Hospital Universitario QuironSalud | Recruiting | Madrid | 28223 | Spain |
| Hospital Universitario Virgen De La Victoria | Recruiting | Málaga | 29010 | Spain |
| Hospital Clinico Universitario De Valencia | Recruiting | Valencia | 46010 | Spain |
| Hospital Clinico Universitario De Valladolid | Recruiting | Valladolid | 47003 | Spain |
| Hospital Clinico Universitaro De Valladolid | Recruiting | Valladolid | 47011 | Spain |
| Hirslanden Klinik-Tumor Zentrum Aarau | Recruiting | Aarau | 5000 | Switzerland |
| Kantonsspital St Gallen | Recruiting | Sankt Gallen | 9007 | Switzerland |
| UniversitaetsSpital Zurich | Recruiting | Zurich | 8091 | Switzerland |
| Betsi Cadwaladr University Health Board - Glan Clwyd District General Hospital | Recruiting | Bodelwyddan | Denbighshire | LL18 5UJ | United Kingdom |
| University Hospitals Birmingham NHS Foundation Trust (UHB) - UHB-Queen Elisabeth Medical Centre | Recruiting | Birmingham | B15 2TH | United Kingdom |
| Royal Orthopaedics Hospital, NHS Trust | Active, not recruiting | Birmingham | B312AP | United Kingdom |
| Cambridge University Hospital NHS - Addenbrookes Hospital | Recruiting | Cambridge | CB2 0QQ | United Kingdom |
| Velindre NHS Trust - Velindre Cancer Centre | Recruiting | Cardiff | CF14 2TL | United Kingdom |
| University Hospitals Coventry and Warwickshire NHS Trust - University Hospital | Recruiting | Coventry | CV2 2DX | United Kingdom |
| NHS Lothian - Western General Hospital | Recruiting | Edinburgh | EH4 2XU | United Kingdom |
| NHS Greater Glasgow and Clyde - Beatson West of Scotland Cancer Centre - Gartnavel General Hospital | Recruiting | Glasgow | G12 OYN | United Kingdom |
| Hereford County Hospital | Recruiting | Hereford | HR1 2ER | United Kingdom |
| Leeds Teaching Hospitals NHS Trust - St. James's University Hospital | Recruiting | Leeds | LS9 7TF | United Kingdom |
| The Clatterbridge cancer Center NHS foundation Trust - Clatterbridge Cancer Center - Liverpool | Recruiting | Liverpool | L7 | United Kingdom |
| Royal Free Hospital | Recruiting | London | NW3 2QG | United Kingdom |
| The Christie NHS Foundation Trust | Recruiting | Manchester | M20 4BX | United Kingdom |
| ID | Term |
|---|---|
| D009369 | Neoplasms |
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