Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The purpose of this study is to investigate the safety, tolerability and pharmacokinetics of MT-7117 in healthy subjects.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Single ascending dose, MT-7117 or Placebo | Experimental |
| |
| Multiple ascending dose, MT-7117 or Placebo | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MT-7117 | Drug |
| ||
| Placebo |
| Measure | Description | Time Frame |
|---|---|---|
| Safety and Tolerability as measured by number of participants with adverse events | up to Day56 | |
| Safety and Tolerability as measured by vital signs | up to Day56 | |
| Safety and Tolerability as measured by physical examination | up to Day56 | |
| Safety and Tolerability as measured by ECG | up to Day21 | |
| Safety and Tolerability as measured by laboratory safety assessments | up to Day21 |
| Measure | Description | Time Frame |
|---|---|---|
| Maximum plasma concentration (Cmax) | 96 hours post dose | |
| Area under the plasma concentration-time curve (AUC) | 96 hours post dose | |
| Time to maximum plasma concentration (Tmax) |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Investigational center | United Kingdom | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39887900 | Derived | Ogasawara A, Ide R, Inoue S, Tsuda M, Teng R. Assessment of Potential Drug-Drug Interactions for Novel Oral Melanocortin-1 Receptor Agonist Dersimelagon. Pharmacol Res Perspect. 2025 Feb;13(1):e70069. doi: 10.1002/prp2.70069. | |
| 37060458 | Derived | Ogasawara A, Ogawa K, Ide R, Ikenaga Y, Fukunaga C, Nakayama S, Tsuda M. Results from a first-in-human study of dersimelagon, an investigational oral selective MC1R agonist. Eur J Clin Pharmacol. 2023 Jun;79(6):801-813. doi: 10.1007/s00228-023-03476-6. Epub 2023 Apr 15. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Drug |
|
| 96 hours post dose |
| Apparent elimination half-life in plasma | 96 hours post dose |