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The purpose of this study is to evaluate the effect of muscle ischemia during claudication on mitochondrial function.
Comparison to patients with arterial disease but absence of lower limb claudication (Cardiac group) feasibility study.
Assess the feasibility of the study of micro-vascular function and mitochondrial on muscle sample (sartorius) in a group of arterial disease and non arteriopathy group.
Analysis of the activity of mitochondrial chain Immunochemistry of tissue markers
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Peripheral artery diseased group | Active Comparator | pad Patients referred for femoro popliteal bypass Muscle biopsy during surgery |
|
| Cardiac group | Sham Comparator | Patients referred for saphenous withdrawal for coronary bypass Muscle biopsy during surgery |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Muscle Biopsy | Other | A distal and proximal biopsy of the sartorius muscles ( 0.5 cm3 each) will be performed during surgery for saphenous vein withdrawal (cardiac group) or arterial bypass (PAD group) The samples are then treated with neurovascular and mitochondrial biology laboratory. the activity of the complex 1 is analyzed and compared between the 2 groups. |
| Measure | Description | Time Frame |
|---|---|---|
| Activity differences in mitochondrial complex I between the distal and proximal levy in group 1 and group 2. | Measurement of mitochondrial complex 1 activity (arbitrary units) on muscle biopsies by the laboratory of biochemistry. Comparison of the results observed on the same miuscle at the proximal level (assumed normal in both groups) and distal level (assumed ischemic in claudicants but not in cardiac patients without limb symptoms. | 1 week |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Pierre ABRAHAM, PROFESSOR | UH ANGERS | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Uh Angers | Angers | 49933 | France |
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| ID | Term |
|---|---|
| D007511 | Ischemia |
| D058729 | Peripheral Arterial Disease |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D050197 | Atherosclerosis |
| D001161 | Arteriosclerosis |
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|
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D016491 | Peripheral Vascular Diseases |