Cognitive-motor Intervention Using Virtual Reality for Middle-aged Individuals at High Dementia Risk

Cognitive-motor Intervention Using Virtual Reality for Middle-aged Individuals at High Dementia Risk

The primary objective of this program is to apply a virtual reality (VR) cognitive-motor intervention (compared to active and passive control groups) to delay or slow cognitive decline of middle-aged adults who have a family history of Alzheimer's disease (AD) and thus are at particularly high risk of developing the disease.

Inclusion Criteria:

• The participants of the study must have at least one parent with Alzheimer's disease.
• Fluency in Hebrew, in order to understand the instructions of the cognitive tests.
• Availability of an informant for the participant.

Exclusion Criteria:

• Severe neurological or psychological conditions that may affect cognitive performance.
• Substantial orthopedic limitations which prevent the use of treadmill.
• Unstable medical condition such as an active cancer.
• Incapability of adherence to the training program.
• The participant is undergoing a treatment that may interfere with the study program.