Efffect of a single dose oral intake of sildenafil Or placebo on the walking capacity on treadmill of PAD patients with claudication

Sildenafil 100mg or Placebo Oral intake 2 hours before the treadmill test Safety and security control throughout the period of drug efficacy (approx 4 hours) Evaluation of maximal walking distance for a constant load treadmill test (3.2 kml/h 10% slope)

Inclusion Criteria:

• Patient with peripheral arterial desease stade II
• Patient with vascular claudication for at least 3 months
• Patient able to perform a treadmill walking test with time to walk < 5min

Exclusion Criteria:

• Patient suffering from ischemia
• Previous angina or myocardial
• Patient treated with nitrates drugs
• Patient with severe renal insufficiency
• Patient with severe hepatic insufficiency
• Patient with hypotension