Green Tea Extract for Endometriosis Treatment

Randomised Double-blinded Placebo Controlled Trial of Green Tea Extract for Endometriosis

The purpose of the study is to evaluate the efficacy and safety of green tea in endometriosis.

Women with endometrioma will be randomised into either the experimental group or the placebo comparator group in a 1:1 ratio. The subjects will be given SUNPHENON EGCg or placebo for 3 months prior to their planned surgery.

Inclusion Criteria:

• Complaints of pelvic pain, dysmenorrhoea and/or dyspareunia ≥ 6 months; and
• Verbal pain rating scale > 4/10 and visual analogue pain scale > 4cm; and
• Ultrasound confirmed endometrioma with or without fibroid and adenomyoma; and
• Planned surgery treatment within 4-6 months

Exclusion Criteria:

• Age < 20 years beyond or >40 year behind the active reproductive age; or
• BMI <18.5 kg/m2 as underweight or >25 kg/m2 as overweight; or
• Chronic pelvic pain or low back pain due to other medical conditions, e.g. urological disorders and orthopaedic disorders; or
• Secondary dysmenorrhoea due to gynaecological conditions other than endometriosis, e.g. pelvic inflammatory diseases, genitourinary infections, gynaecological tumours, etc.; or
• Primary dysmenorrhoea without any underlying disease identified; or
• Ultrasound suggested polycystic ovary, haemorrhagic ovarian cyst, ovarian dermoid cyst, cystic neoplasm, tubo-ovarian abscess or other ovarian pathologies in the same ovary; or
• Chronic medical conditions under long-term medications; or
• Endometriosis under active medication in past 1 month; or
• History of herbal medicine intake in past 1 month