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The purpose of this study is to explore the perinatal risk factors of encephalopathy of prematurity and the morbidity of the following neurodevelopmental impairments in preterm infants with gestational age <32 weeks in China.
Recent years have witnessed an increase in survival of very or extremely low birth weight infants, with a corresponding increase of attention to encephalopathy of prematurity (EOP) and the following neurological disorders. Studies suggested that hypoxic-ischemic injury and perinatal infection might be the two main risk factors of EOP, including white matter injury, neuronal-axonal diseases and cerebellar hemorrhage, which have a strong impact on neurological outcomes. Sequelae like cerebral palsy or mental retardation become a burden to both the family and society. Therefore, the risk factors of brain injury become the critical issue of both Obstetrics and Neonatology. More importantly, little is known about the morbidity of neurodevelopmental impairment and its risk factors in China. Thus, the aim of our study is to explore the perinatal risk factors of encephalopathy of prematurity and the morbidity of the following neurodevelopmental impairments in preterm infants with gestational age <32 weeks in China.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| encephalopathy of prematurity | infants with encephalopathy of prematurity showed on MRI at term-equivalent age | ||
| no encephalopathy of prematurity | infants with no encephalopathy of prematurity showed on MRI at term-equivalent age |
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| Measure | Description | Time Frame |
|---|---|---|
| developmental quotient (DQ) on the Gesell Developmental Schedules | Result of gross motor, fine motor, language and social test. DQ = Development Age / Chronological Age X 100 | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| brain injury showed on MRI | signal abnormality in white matter, grey matter or cerebellum injury; periventricular leukomalacia; intracranial hemorrhage | 36-40 weeks' postmenstrual age or before discharge |
| morbidity of encephalopathy of prematurity |
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Inclusion Criteria:
Exclusion Criteria:
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neonatal intensive-care units
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| Name | Affiliation | Role |
|---|---|---|
| Chao Chen, PhD, MD | Children's Hospital of Fudan University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The First People's Hospital of Hefei | Hefei | Anhui | 230000 | China | ||
| Xiamen Women's and Children's Health Centre |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 15995055 | Background | Volpe JJ. Encephalopathy of prematurity includes neuronal abnormalities. Pediatrics. 2005 Jul;116(1):221-5. doi: 10.1542/peds.2005-0191. No abstract available. | |
| 20064132 | Background | Groenendaal F, Termote JU, van der Heide-Jalving M, van Haastert IC, de Vries LS. Complications affecting preterm neonates from 1991 to 2006: what have we gained? Acta Paediatr. 2010 Mar;99(3):354-8. doi: 10.1111/j.1651-2227.2009.01648.x. Epub 2010 Jan 8. |
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| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D047928 | Premature Birth |
| ID | Term |
|---|---|
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D007752 | Obstetric Labor, Premature |
| D007744 | Obstetric Labor Complications |
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serum, tissue
white matter injury, grey matter injury, cerebellum injury on MRI
| 36-40 weeks' postmenstrual age or before discharge |
| all cause mortality | Mortality that does not require judgments about the cause of death | 2 years |
| neurodevelopment sequelae | including cerebral palsy, epilepsy, hearing loss, vision loss, etc. | 2 years |
| Xiamen |
| Fujian |
| 361000 |
| China |
| People's Hospital of Zhangzhou | Zhangzhou | Fujian | 363000 | China |
| The Second Affiliated Hospital of Guangzhou Medical University | Guangzhou | Guangdong | 510260 | China |
| Zhongshan Bo Ai Hospital | Zhongshan | Guangdong | 582400 | China |
| Maternal and Child Health Hospital of Guiyang Province | Guiyang | Guizhou | 550003 | China |
| Handan Central Hospital | Handan | Hebei | 056001 | China |
| First Hospital of Jilin University | Changchun | Jilin | 130021 | China |
| Children's Hospital of Fudan University | Shanghai | Shanghai Municipality | 201102 | China |
| Shanghai First Maternity and Infant Hospital | Shanghai | Shanghai Municipality | 201204 | China |
| Shanxi Provincial Maternity and Children's Hospital | Xian | Shanxi | 710061 | China |
| First Affiliated Hospital of Xinjiang Medical University | Ürümqi | Xinjiang | 830054 | China |
| First Affiliated Hospital of Kunming Medical University | Kunming | Yunnan | 650032 | China |
| Ningbo Women's and Children's Hospital | Ningbo | Zhejiang | 315012 | China |
| 19081519 | Background | Volpe JJ. Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. Lancet Neurol. 2009 Jan;8(1):110-24. doi: 10.1016/S1474-4422(08)70294-1. |
| 25205706 | Background | Korzeniewski SJ, Romero R, Cortez J, Pappas A, Schwartz AG, Kim CJ, Kim JS, Kim YM, Yoon BH, Chaiworapongsa T, Hassan SS. A "multi-hit" model of neonatal white matter injury: cumulative contributions of chronic placental inflammation, acute fetal inflammation and postnatal inflammatory events. J Perinat Med. 2014 Nov;42(6):731-43. doi: 10.1515/jpm-2014-0250. |
| 21907243 | Background | Sominsky L, Walker AK, Ong LK, Tynan RJ, Walker FR, Hodgson DM. Increased microglial activation in the rat brain following neonatal exposure to a bacterial mimetic. Behav Brain Res. 2012 Jan 1;226(1):351-6. doi: 10.1016/j.bbr.2011.08.038. Epub 2011 Sep 1. |
| 20664400 | Background | Shatrov JG, Birch SCM, Lam LT, Quinlivan JA, McIntyre S, Mendz GL. Chorioamnionitis and cerebral palsy: a meta-analysis. Obstet Gynecol. 2010 Aug;116(2 Pt 1):387-392. doi: 10.1097/AOG.0b013e3181e90046. |
| 24625113 | Background | Howson CP, Kinney MV, McDougall L, Lawn JE; Born Too Soon Preterm Birth Action Group. Born too soon: preterm birth matters. Reprod Health. 2013;10 Suppl 1(Suppl 1):S1. doi: 10.1186/1742-4755-10-S1-S1. Epub 2013 Nov 15. |
| 20961565 | Background | Hendson L, Russell L, Robertson CM, Liang Y, Chen Y, Abdalla A, Lacaze-Masmonteil T. Neonatal and neurodevelopmental outcomes of very low birth weight infants with histologic chorioamnionitis. J Pediatr. 2011 Mar;158(3):397-402. doi: 10.1016/j.jpeds.2010.09.010. Epub 2010 Oct 18. |
| 21535310 | Background | Sato M, Nishimaki S, Yokota S, Seki K, Horiguchi H, An H, Ishida F, Fujita S, Ao K, Yatake H. Severity of chorioamnionitis and neonatal outcome. J Obstet Gynaecol Res. 2011 Oct;37(10):1313-9. doi: 10.1111/j.1447-0756.2010.01519.x. Epub 2011 May 3. |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |