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The purpose of this study is to determine: (1) whether laparoscopy-assisted nerve-preserved total mesorectal excision (LNTME) is as safe as open TME for rectal cancer, and (2) whether LNTME is more effective for protection of pelvic autonomic nerve function from surgical impairing when comparing to open TME.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| LNTME | Experimental | Laparoscopy-assisted nerve-preserved TME (LNTME) is conducted in rectal cancer patients |
|
| OTME | Active Comparator | Open TME (OTME) is conducted in rectal cancer patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| LNTME | Procedure | Patients in this group received laparoscopy-assisted nerve-preserved TME for treatment of rectal cancer |
|
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative complications including bleeding, anastomotic leakage, postoperative infection, organ dysfunctions. | postoperative 30 days | |
| The postoperative sexual function assessed by IIEF questionnaire | postoperative one year | |
| The postoperative voiding function assessed by IPSS questionnaire. | postoperative one year |
| Measure | Description | Time Frame |
|---|---|---|
| Operative time | an expected average of 180 minutes | |
| Postoperative deaths | postoperative 30 days | |
| The length postoperative hospital stay |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Han-Hui HH YAO, M.D. | Contact | +86-18956087855 | ruoyubaba@163.com | |
| Liu L LIU, PhD | Contact | +86-15056017712 | liuwkjy@126.com |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29682715 | Derived | He Y, Zhu Z, Liu S, Liu L, Hu B, Wan X, Huang Q. [Effect of anastomotic reinforcing sutures on the incidence of anastomotic leakage after laparoscopic radical resection of rectal cancer: a prospective randomized controlled trial]. Zhonghua Wei Chang Wai Ke Za Zhi. 2018 Apirl 25;21(4):431-436. Chinese. |
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| ID | Term |
|---|---|
| D012004 | Rectal Neoplasms |
| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
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| OTME | Procedure | Patients in this group received traditional open TME for treatment of rectal cancer |
|
| an expected average 8 days |
| C-reactive protein | serum C-reactive protein level after operation | postoperative 7 days |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |