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Autism Spectrum Disorders (ASD) is a neurodevelopmental disorder which involves social and behavioural impairments. Autonomic dysfunctions and disturbed sleep were often associated to ASD. The investigators proposed to explore the impact of physical activity on these disorders. In this context, it is necessary to characterize the cardiorespiratory capacities of ASD children in order to promote physical activity for this population. To examine potential differences between ASD and control children, some explorations were proposed: a maximal treadmill test, motor evaluation, and orthostatic test (for the evaluation of autonomic nervous system).
An actimetry during one week (evaluation of physical activity and sleep) completed this study in order to specify sleep characteristic and established the possible link between physical activity sleep characteristics and physical fitness in ASD children.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients | Experimental | Children from 8 to 18 years with autism without without intellectual disabilities (IQ > 70), verbals and responding to classification CIM 10-DSM IV. |
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| Healthy volunteers | Experimental | Paired for age, gender, IQ and and the practice of a physical activity strictly within the school context. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| physiological explorations | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| cardiorespiratory evaluation | a maximal treadmill test is proposed (evaluation of : VO² max, maximal heart rate) | 1 day |
| autonomic nervous system evaluation | an orthostatic test is proposed in order to verify the ANS adaptation. A nocturnal recording is made during three nights in order to verify the possible link between the rest autonomic adaptations and a possible dysautonomia observed with the orthostatic test. | 1 day and 3 nights |
| sleep evaluation | Sleep characteristics are obtained by an actimetry during 7 nights in order to observe sleep disorders. Sleep Questionnaires are also completed. | 7 nights |
| Measure | Description | Time Frame |
|---|---|---|
| physical activity | physical activity characteristics (sedentary, moderate or vigorous activities, energy expenditure) are obtained by an actimetry during 7 days. Questionnaires of physical activity are also completed | 7 days |
| Motor capacities |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Véronique BRICOUT, PhD | CHU Grenoble France | Principal Investigator |
| Michel GUINOT, Dr | CHU Grenoble France | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Grenoble | Grenoble | 38100 | France |
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| ID | Term |
|---|---|
| D001342 | Autonomic Nervous System Diseases |
| D000067877 | Autism Spectrum Disorder |
| ID | Term |
|---|---|
| D009422 | Nervous System Diseases |
| D002659 | Child Development Disorders, Pervasive |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
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motor capacities are evaluated by several specific tests : PANESS, M-ABS and Eurofit.
| 1 day |
| Behavioural characteristics | Behavioural characteristics are evaluated by the Vineland scale | 1 hour |
| biological parameters | during the maximal treadmill test, salivary samples are made (cortisol, alpha amylase), before and after tthe test | 1 day |