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The peritoneum is the second most common site of recurrence in patients with colorectal cancer. Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy improve the prognosis of these patients and incorporates surgical removal of all visible disease followed by chemical destruction of microscopic disease through chemoperfusion. The most validated predictors of outcome are preoperative tumor burden measured in terms of the peritoneal carcinomatosis index (PCI) and completeness of cytoreduction (CC score). Diagnostic laparoscopy prior to resection is widely used in hepatopancreaticobiliary and colorectal cancer and has been shown to be effective in excluding unnecessary laparotomy associated with higher morbidity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Digestive peritoneal carcinomatosis staging | All patients underwent laparoscopic followed by laparotomic surgical staging. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Non interventional | Other | Peroperative data collection |
|
| Measure | Description | Time Frame |
|---|---|---|
| Peritoneal carcinomatosis staging | To score the Collect detailed detailed Peritoneal Cancer Index (PCI) by laparoscopy following the laparotomy procedure in order to evaluate the accuracy and adequacy of laparoscopic surgical staging comparing to laparotomic approach. | during laparoscopy and during laparotomy (Day 1) |
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Inclusion Criteria:
Exclusion Criteria:
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Prospectively diagnosed patients initially treated with surgery and adjuvant chemotherapy who have a high risk of developing colorectal peritoneal carcinomatosis.
All patients will receive the current standard adjuvant treatment: 6 months of systemic chemotherapy (currently the Folfox-4 regimen which could be modified if the standard is modified). Then a work-up is done to exclude recurrence.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Olivier GLEHEN, Prof | Contact | (0)4 78 862 371 | +33 | olivier.glehen@chu-lyon.fr |
| Peggy JOURDAN-ENFER | Contact | (0)4 78 864 534 | +33 | peggy.jourdan-enfer@chu-lyon.fr |
| Name | Affiliation | Role |
|---|---|---|
| Olivier GLEHEN, Prof | Hospices Civils de Lyon - Centre Hospitalier Lyon Sud - Service de Chirurgie Générale et Digestive - 165 chemin du grand Revoyet, PIERRE-BENITE, FRANCE, 69495 | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospices Civils de Lyon - Centre Hospitalier Lyon Sud Service de Chirurgie Générale et Digestive - 165 chemin du grand Revoyet | Recruiting | Pierre-Bénite | 69495 | France |
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