For more information regarding Bristol-Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com
Inclusion Criteria:
- Must have advanced liver cancer that cannot be treated with surgery or other local methods
- Liver cancer is confirmed by a microscopic examination of tissue
- Liver disease is classified as 'A' by a standard method called Child-Pugh score
- Daily living abilities are classified as '0 or 1' by a standard method from the Eastern Cooperative Oncology Group (ECOG)
- Women must use contraception
Exclusion Criteria:
- Prior liver transplant
- Increase in blood pressure in some of the veins entering the liver
- Cancer that has spread to the brain or the layers of tissue that cover the brain or spinal cord
- Infection with both hepatitis B and C, both hepatitis D and B, infection with HIV, or other infections
- Disease of the heart or blood vessels around the heart
- Active cancers within the last 2 years
- No more than 2 prior systemic treatments or other investigational agents except PD-1/PD-L1 or Ipilimumab (Part 2)
- Currently on anti-platelet or anti-coagulation therapy
- Radiotherapy within 4 weeks of treatment
- Any major allergies
Other protocol defined inclusion/exclusion criteria could apply