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| ID | Type | Description | Link |
|---|---|---|---|
| 2016-00140 | Other Identifier | Ethics Committee Northwest and Central Switzerland |
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Insufficient enrollment of eligible patients
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| Name | Class |
|---|---|
| Universität Luzern | OTHER |
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Neurocognitive Disorder (NCD) affects over 116'000 people in Switzerland and is frequently unrecognized and underdiagnosed. Because missed and delayed diagnosis are associated with an increased burden of disease health Service Research has prompted a discussion about diagnostic guidelines and screening programs. Some argue that screening for NCD in primary care is the optimal strategy to increase recognition rates; others consider test protocols implemented into hospital admission assessments as more justified. There is no distinct recommendation due to a lack of empirical data on the benefits and harms of cognitive testing yet. This trial strives to fill this gap and provide information about the benefits, harms and the economic case of routine cognitive testing for neurocognitive disorder in high risk elective inpatients, in Switzerland.
The investigators hypothesize that, cognitive tested patients, compared with patients not cognitive tested, will have higher health-related quality of life at 12months; and lower medical health care costs at 18months.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention-Group | Experimental |
| |
| Control-Group | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| BRAINCHECK | Other | Subjects of the Intervention-Group will undergo a brief cognitive assessment, using the BRAINCHECK, during hospital admission assessments. Subjects with positive results will then be referred to a Memory Clinic undergoing subsequent interdisciplinary comprehensive diagnostic examinations. Patients with established diagnosis will be invited to counselling services of the Alzheimer Association (providing social counselling). |
| Measure | Description | Time Frame |
|---|---|---|
| Health related quality of life (HRQoL) | Patient and Caregiver, using EuroQol 5D-5L | every month during 18months |
| Health Service Resource Utilization / Costs | Patient and Caregiver, using Resource Utilization in Dementia (RUD) | every month during 18months |
| Measure | Description | Time Frame |
|---|---|---|
| prevalence of neurocognitive disorder | at Hospital admission | baseline/6months |
| prevalence of risk factors associated with developing major neurocognitive disorder within 6 years | at Hospital Admission, using Brief Dementia Screening Indicator (BDSI) |
| Measure | Description | Time Frame |
|---|---|---|
| caregiver burden | caregiver data, short Zarit Burden Interview (ZBI) | every 3 months |
| adverse events/adverse outcomes | falls, delirium, mortality, mortality within 30 days of discharge, re-admission within 18 days, institutionalization following hospitalization, length of stay |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Stefan Boes, Prof.Dr. | University of Lucerne,Department of Health Sciences & Health Policy | Principal Investigator |
| Thomas Nyffeler, Prof.Dr.med. | Cantonal Hospital of Lucerne | Study Chair |
| Aljoscha Benjamin, M.A. (HSG) | Cantonal Hospital of Lucerne | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cantonal Hospital of Lucerne | Lucerne | Canton Lucerne | 6000 | Switzerland |
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| ID | Term |
|---|---|
| D019965 | Neurocognitive Disorders |
| D003704 | Dementia |
| ID | Term |
|---|---|
| D001523 | Mental Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| baseline/6months |
| between baseline and 6months |
| comorbidities | patient data, using Charlson Comorbidity Index | baseline |
| neuropsychiatric symptoms | patient data during Hospital stay, using Neuropsychiatric Inventory Questionnaire (NPI-Q) | between baseline and 6months |
| hospital anxiety and depression | patient and caregiver data, using Hospital Anxiety and Depression Scale (HADS) | every 3 months |
| severity of cognitive impairment | patients of the Intervention-Group will be assessed every months, using the Montreal Cognitive Assessment (MOCA) | every 6 months |