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Given preliminary data in animal (proprietary data) have shown that XXS (a mixture of natural polyphenolic extracts of edible plants) has a significant and favourable effect on oxidative stress notably with a decrease in certain markers of oxidative stress and on plasma lipid parameters, the investigator proposes to study the effect of 6 months of treatment with XXS in a controlled study against placebo in a population of persons presenting a lipid profile at the upper limit of normal.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| XXS | Experimental |
| |
| Placebo | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| XXS | Dietary Supplement |
| ||
| non-XXS |
| Measure | Description | Time Frame |
|---|---|---|
| Quantification of Malondialdehyde (MDA) | Change from baseline at 1 month, 3 months, 6 months after treatment with XXS | |
| Quantification of oxidized Low Density Lipoprotein (LDL) | Change from baseline at 1 month, 3 months, 6 months after treatment with XXS |
| Measure | Description | Time Frame |
|---|---|---|
| Measure of overall free-radical defences in the blood by KRL Kyrial Internationaltest | Change from baseline at 1 month, 3 months, 6 months after treatment with XXS |
| Measure | Description | Time Frame |
|---|---|---|
| Quantification of LDL | Change from baseline at 1 month, 3 months, 6 months after treatment with XXS | |
| Quantification of High Density Lipoprotein (HDL) | Change from baseline at 1 month, 3 months, 6 months after treatment with XXS |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier Universitaire | Dijon | 21079 | France |
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