Study to Evaluate the Effects of XXS on Oxidative Stress in Patients With Mild or Moderate Hyperlipidemia

Randomized, Double-blind Study to Evaluate the Effects of XXS on Oxidative Stress in Patients With Mild or Moderate Hyperlipidemia and on Lipoprotein Kinetics

Given preliminary data in animal (proprietary data) have shown that XXS (a mixture of natural polyphenolic extracts of edible plants) has a significant and favourable effect on oxidative stress notably with a decrease in certain markers of oxidative stress and on plasma lipid parameters, the investigator proposes to study the effect of 6 months of treatment with XXS in a controlled study against placebo in a population of persons presenting a lipid profile at the upper limit of normal.

Inclusion Criteria:

• Persons who have provided written consent
• Persons aged over 18 years
• Presenting LDL levels between 1.30 and 1.90 g/l and/or triglyceride levels between 1.5 and 3 g/l

Exclusion Criteria:

• Persons without national health insurance cover
• Pregnant or breastfeeding women
• Adults under guardianship
• Patients with diabetes (Insulin-Dependent Diabetes (IDD) or Non-Insulin-Dependent Diabetes NIDD)
• Patients with coronary artery disease
• Patients with atherosclerosis
• HDL>0.80 g/l
• receiving treatment with lipid-lowering agents (statins, fibrates, ezetimibe or Ω3)
• Consuming vitamin supplements (A, C, E…)
• Consuming oligoelements or minerals (Se, Zn, Ca…)
• Renal insufficiency (creatinine clearance < 30 ml/min calculated according to the Modification of the Diet in Renal Disease (MDRD))