Protective Effects of Exercise Training

Protective Effects of Exercise Training on Endothelial Dysfunction Induced by Total Sleep Deprivation in Healthy Subjects

Rationale. Sleep loss is a risk factor for cardiovascular events mediated through endothelial dysfunction.

Objective. To determine if 7 weeks of exercise training can limit cardiovascular dysfunction induced by total sleep deprivation (TSD) in healthy young men.

Methods: 16 subjects will be examined during 40-h TSD, both before and after 7 weeks of interval exercise training. Vasodilatation induced by ACh, insulin and heat (42°C) as well as pulse wave velocity (PWV), blood pressure and heart rate (HR) will be assessed at baseline, during TSD, and after one night of sleep recovery. Biomarkers of endothelial activation, inflammation, and hormones will bemeasured from morning blood samples at 07:00

Inclusion Criteria:

• Healthy
• Men
• 18 - 35 yrs

Exclusion Criteria:

• Consumming 400 mg of caffeine per day,
• Body mass index (BMI) greater than 30 kg/m²,
• Taking medication.
• Excessive daytime somnolence (Epworth Sleepiness Scale >9)
• Sleep complaints (Pittsburgh Sleep Quality Index >5)
• Inability to be considered as an intermediate chronotype on the Horne and Ostberg questionnaire (score <31 or >69)
• Traines subject (Ricci Gagnon questionnaire >35)