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| ID | Type | Description | Link |
|---|---|---|---|
| 2014_A01103-44 | Other Identifier | IDRCB ANSM |
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| Name | Class |
|---|---|
| Cetre du sommeil et de la vigilance, APHP | UNKNOWN |
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Rationale. Sleep loss is a risk factor for cardiovascular events mediated through endothelial dysfunction.
Objective. To determine if 7 weeks of exercise training can limit cardiovascular dysfunction induced by total sleep deprivation (TSD) in healthy young men.
Methods: 16 subjects will be examined during 40-h TSD, both before and after 7 weeks of interval exercise training. Vasodilatation induced by ACh, insulin and heat (42°C) as well as pulse wave velocity (PWV), blood pressure and heart rate (HR) will be assessed at baseline, during TSD, and after one night of sleep recovery. Biomarkers of endothelial activation, inflammation, and hormones will bemeasured from morning blood samples at 07:00
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise training | Experimental | 7 weeks of exercise training |
|
| Control | Sham Comparator | Sedentary group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sleep deprivation | Other | 40 hours of continuous wakefullness |
|
| Measure | Description | Time Frame |
|---|---|---|
| ACh induced Vasodilation during TSD | Cutaneous vasodilation (in % Baseline) induced by local application of Acethylcholine | Up to 09:00 during sleep deprivation (i.e. after 26 hours of wakefulness) |
| Measure | Description | Time Frame |
|---|---|---|
| Insuline Vasodilation | Cutaneous vasodilation (in % Baseline) induced by local application of insulin | Up to 09:00 during the sleep deprivation day and the recovery day |
| Heat vasodilation | Cutaneous vasodilation (in % Baseline) induced by local application of heat (42°C) |
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Inclusion Criteria:
Exclusion Criteria:
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25932797 | Background | Sauvet F, Drogou C, Bougard C, Arnal PJ, Dispersyn G, Bourrilhon C, Rabat A, Van Beers P, Gomez-Merino D, Faraut B, Leger D, Chennaoui M. Vascular response to 1 week of sleep restriction in healthy subjects. A metabolic response? Int J Cardiol. 2015;190:246-55. doi: 10.1016/j.ijcard.2015.04.119. Epub 2015 Apr 16. | |
| 26647769 | Background |
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| ID | Term |
|---|---|
| D012892 | Sleep Deprivation |
| ID | Term |
|---|---|
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |
| D009461 | Neurologic Manifestations |
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| Up to 9:00 during the sleep deprivation day and during the recovery day |
| Inflammation | Plasma levels of inflammatory marquers (TNF-alpha, IL1beta...) | Up to 7:00 during the sleep deprivation day and during the recovery day. |
| blood pressure | Mean, systolic and diastolic blood pressure | Every 3 hours during the 40 hours of wakefullness (i.e. total sleep deprivation) |
| PWV | Pulse wave velovity evaluated by echography | Up to 09:00 during the sleep deprivation day |
| Arnal PJ, Drogou C, Sauvet F, Regnauld J, Dispersyn G, Faraut B, Millet GY, Leger D, Gomez-Merino D, Chennaoui M. Effect of Sleep Extension on the Subsequent Testosterone, Cortisol and Prolactin Responses to Total Sleep Deprivation and Recovery. J Neuroendocrinol. 2016 Feb;28(2):12346. doi: 10.1111/jne.12346. |
| 26194565 | Background | Arnal PJ, Sauvet F, Leger D, van Beers P, Bayon V, Bougard C, Rabat A, Millet GY, Chennaoui M. Benefits of Sleep Extension on Sustained Attention and Sleep Pressure Before and During Total Sleep Deprivation and Recovery. Sleep. 2015 Dec 1;38(12):1935-43. doi: 10.5665/sleep.5244. |
| 28089456 | Derived | Sauvet F, Arnal PJ, Tardo-Dino PE, Drogou C, Van Beers P, Bougard C, Rabat A, Dispersyn G, Malgoyre A, Leger D, Gomez-Merino D, Chennaoui M. Protective effects of exercise training on endothelial dysfunction induced by total sleep deprivation in healthy subjects. Int J Cardiol. 2017 Apr 1;232:76-85. doi: 10.1016/j.ijcard.2017.01.049. Epub 2017 Jan 5. |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001523 | Mental Disorders |