This study evaluates the delivery of substance P via the celiac artery in the treatment of recent onset type 1 diabetes.

Inclusion Criteria:

• Recent onset T1D (CDA 2013 guidelines: See link in links section
• Age 10-18 years
• Disease Duration 3-30 months
• Fasting C-Peptide (measured at screening) greater than or equal to 33 pmol/L
• Post honeymoon phase based on the following criteria: History of HbA1c values and insulin requirements from diagnosis indicating a honeymoon period followed by increased insulin requirements which at time of recruitment are > 0.50 units/Kg together with an HbA1c value > 7.2 %; Patients with diabetes duration > 3 months who never experienced a honeymoon period as reflected by consistent HbA1c values > 7.2 % from the time of diagnosis and at the time of recruitment are using an insulin dose > 0.50 units/Kg.
• The presence of one or more of the TRPV1 alleles similar to those found in patients currently enrolled in the TRPV1-North American - European Study.
• Stimulated C-Peptide (measured at mixed meal tolerance at Stage A and Stage B of sP trial) ≥ 200 pmol/L and less than or equal to 1500 pmol/L.

Exclusion Criteria:

• Patients with known co-morbidities, including ACE-inhibitor treated hypertension as well as chromosomal abnormalities, involving one or more organ systems.
• Type 2 Diabetes Mellitus
• Patients with a known radiographic contrast allergy
• Pregnancy.