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| ID | Type | Description | Link |
|---|---|---|---|
| PSS 2016 / DOVISCAN - MANDRY / | Other Identifier | CentralHNF |
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| Name | Class |
|---|---|
| Institut National de la Santé Et de la Recherche Médicale, France | OTHER_GOV |
| University of Lorraine | OTHER |
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The purpose of this study is to assess the degree of agreement of the measurement of differential renal function in living donors by CT (computed tomography) and SPECT (single photon emission computed tomography).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| All patients | Other | Differential renal function assessment by 4D CT: All patients will undergo both CT and SPECT assessment of differential renal function; each patient will be his own comparator |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Differential renal function assessment by 4D CT | Other | Low dose 4D (perfusion) renal acquisition after injection of iodinated contrast medium (ICM) (13 passes every 3 seconds, 3 passes every 10 seconds); estimated additional DLP 400 mGy.cm No additional contrast medium |
| Measure | Description | Time Frame |
|---|---|---|
| degree of agreement | Differential renal function (DRF) measured by each technique (CT and SPECT) Regions of interest will be drawn on each kidney and the aorta to obtain time-intensity curves and derive the Patlak plot; the Patlak model will then be used to determine the slope of each kidney and thus to calculate the differential renal function (percentage of each kidney in the total renal function). Degree of agreement will be assessed by calculating the intra-class correlation coefficient and its 95% confidence interval, and the Bland-Altman plot. | through study completion (2 years) |
| Measure | Description | Time Frame |
|---|---|---|
| Intra- and inter-observer reproducibility of CT DRF measurement | through study completion (2 years) | |
| Radiation dose exposure for each technique | Additional radiation dose exposure (CTDIvol and DLP) will be recorded and follow-up |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Damien Mandry, MD,PhD | CHRU Nancy | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHRU Nancy | Nancy | 54000 | France |
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| 1 day |
| Agreement between post-processing methods for CT | Comparison between Patlak-Ruthland method, its modified version and the area under the curve method | through study completion (2 years) |
| Automatic post-processing for Patlak-Ruthland method | through study completion (2 years) |