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Principle investigator (Sylvia Herbozo) left the university.
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| Name | Class |
|---|---|
| Oregon Research Institute | OTHER |
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This study will examine the effectiveness of food response training interventions in reducing binge eating among adults engaged in binge eating.
Binge eating disorder is the most prevalent eating disorder and affects both men and women at comparable rates unlike anorexia nervosa and bulimia nervosa. Given that binge eating and obesity are strongly associated, binge eating treatments should aim to reduce binge eating as well as weight. However, most binge eating interventions do not produce lasting weight loss. Recent research has shown computer-based response inhibition training with high-calorie foods reduces reward region response to and attentional bias for the training foods, decreases training food intake, increases inhibitory control, and produces weight loss in overweight adults. There is evidence that the weight loss effects from such response training persist through 6-month follow-up. Further, binge eating has been associated with increased food-related impulsivity and increased activation in a reward-processing brain region to high-calorie foods. Prior research suggests that food response training may be an effective intervention for binge eating that teaches automatic self-control in response to high-calorie foods which in turn, reduces binge eating and produces weight loss. This study will examine the effectiveness of food response training interventions in reducing binge eating and weight among adults engaged in binge eating.
The goals of this study are to: (1) test the hypothesis that adults who complete the food response trainings will show significantly greater reductions in binge eating frequency and in body mass index (BMI) compared to generic response training from pretest to posttest and at 3-month follow up, (2) to determine whether one of the food response trainings is more effective in binge eating frequency and reducing BMI from pretest to posttest and at 3-month follow up, and (3) test whether a reduction in valuation of the high-calorie versus low-calorie foods (willingness to pay for the pictured foods) and/or behavioral improvement of inhibitory control during the training tasks mediate the effects of the various trainings on reductions in binge frequency and body mass index.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Go/No-Go Training | Experimental | In the go/no go training, participants are shown images in which high-calorie foods are shown on one side of the screen and low-calorie foods on the other. They are told to press response keys as quickly as possible to indicate the side of presentation (go-trials). On half of the trials, the rectangular frame surrounding the image is not solid but hatched, which is a signal for them to withhold their response (no-go trials). This training is divided into 4 blocks of 50 trials. |
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| Stop-Signal Training | Experimental | In the stop signal training, participants are shown images in either a dark blue or light gray border. They are told to press the space bar as quickly as possible when the border is blue (go trials) and to withhold a response when the border is gray (no-go trials). This training is divided into 20 blocks of 32 trials. |
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| Dot-Probe Training | Experimental | In the dot-probe training, participants are shown images in which high-calorie foods are shown on one side of the screen and low-calorie foods on the other. Immediately after the images disappear, a small dot probe appears in the location of one of the images. Participants are told to press response keys as quickly as possible to indicate whether a visual probe appeared behind the left or right image during the trials. The probe appears in the location occupied by a high-calorie food image 10% of the time and in the location occupied by a low-calorie food image 90% of the time. This training is divided into 6 blocks of 40 trials. |
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| Generic Training |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Go/No-Training | Behavioral |
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| Stop-Signal Training |
| Measure | Description | Time Frame |
|---|---|---|
| Binge Eating Frequency | Number of times engaged in binge eating (self-report) | Post-intervention (at 4 months) |
| Binge Eating Frequency | Number of times engaged in binge eating (self-report) | 3-month follow-up (at 7 months) |
| Measure | Description | Time Frame |
|---|---|---|
| Body Mass Index | Weight in kilograms divided by height in meters squared. | Post-intervention (at 4 months) |
| Body Mass Index | Weight in kilograms divided by height in meters squared. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sylvia Herbozo, Ph.D. | University of Illinois at Chicago | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sylvia Herbozo | Chicago | Illinois | 60607 | United States |
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| ID | Term |
|---|---|
| D002032 | Bulimia |
| D009765 | Obesity |
| D006963 | Hyperphagia |
| ID | Term |
|---|---|
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D050177 | Overweight |
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| Placebo Comparator |
In the generic training, participants complete a generic go/no-go training that uses images of flowers and office supplies instead of the images of high-calorie and low-calorie food images. This generic go/no go training is identical in duration and contact time to the go/no-go food training. |
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| Dot-Probe Paradigm | Behavioral |
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| Generic Response Training | Behavioral |
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| 3-month follow-up (at 7 months) |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |