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| ID | Type | Description | Link |
|---|---|---|---|
| 2016-A00040-51 | Registry Identifier | 2016-A00040-51 |
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| Name | Class |
|---|---|
| Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques | OTHER |
| UFR STAPS | UNKNOWN |
There is growing interest for physical activity in Parkinson's disease in order to improve mobility and function of these patients. It seems from previous studies that difficulty, intensity and specificity of physical exercises are important parameters conditioning the effect of physical activity on cerebral plasticity and clinical improvement.
Thus, the aim of this study is to evaluate the benefits of a Personalized Physical Activity coaching program, including scheduled and frequent follow up associated with progressive readaptation of exercise intensity depending on individual performances (during 3 months), versus free practice of physical activity in Parkinson's disease.
Type of study: a randomized, single-blind, parallel-group, controlled clinical trial.
Number of centers: 1 (Clermont-Ferrand)
Patients
Patients eligible for inclusion will be randomized to one of the two groups:
Study Performance Patients will be evaluated 3 times : at J0 (baseline, V1), 3 months after Personalized Physical Activity coaching program (J0+3M, V2), and 3 months after the end of the Personalized Physical Activity coaching program (J0+6M)
V1:
V1, V2, V3
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| APA+ | Experimental | APA + : patients will beneficiate of Personalized Physical Activity coaching program during 3 months (1 hour, twice by week, during 3 months) |
|
| APA- | Other | APA- : patients will do free practice of physical activity during 3 months. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Personalized Physical Activity coaching program | Behavioral |
| ||
| Free practice of physical activity |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline of the Unified Parkinson Disease Rating Scale part III score | at +3months |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline of Parkinson's Disease Questionnaire 39-item version score | at +3months | |
| Change from baseline of the Lawton and Brody Activities of Daily Living scale score | at +3months | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Patrick LACARIN | Contact | 04 73 75 11 95 | placarin@chu-clermontferrand.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Clermont-Ferrand | Recruiting | Clermont-Ferrand | 63003 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40088781 | Derived | Zanchet C, Lambert C, Boyer T, Pereira B, Derost P, Debilly B, Duclos M, Boisseau N, Marques A. Effect of an adapted physical activity program in Parkinson's disease: A randomized controlled study (APA-Park). Parkinsonism Relat Disord. 2025 May;134:107777. doi: 10.1016/j.parkreldis.2025.107777. Epub 2025 Mar 10. | |
| 38588457 | Derived |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| Behavioral |
|
| Change from baseline of the percentage of sedentarity, mild, moderate and intense activity using the eMOUVE application |
| at +3months |
| Change from baseline of percentage of sedentarity, mild, moderate and intense activity using the eMOUVE application | at + 6 months |
| Change from baseline of balancing abilities measured by stabilometry | at +3months |
| Change from baseline of balancing abilities measured by stabilometry | at + 6 months |
| Change from baseline of muscular strength measured with isometric test | at +3months |
| Change from baseline of muscular strength measured with isometric test | at +6months |
| Change from baseline of VO2pic | at +3months |
| Change from baseline of VO2pic | at + 6 months |
| Change from baseline of the 6 min Walking Test score | at +3 months |
| Change from baseline of the 6 min Walking Test score | at + 6 months |
| Change from baseline of fat and lean body mass measured by DEXA | at +3 months. |
| Change from baseline fat and lean body mass measured by DEXA | at +6 months. |
| dropout rates | at +3 months |
| dropout rates | at +6 months |
| Ernst M, Folkerts AK, Gollan R, Lieker E, Caro-Valenzuela J, Adams A, Cryns N, Monsef I, Dresen A, Roheger M, Eggers C, Skoetz N, Kalbe E. Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2024 Apr 8;4(4):CD013856. doi: 10.1002/14651858.CD013856.pub3. |
| 36602886 | Derived | Ernst M, Folkerts AK, Gollan R, Lieker E, Caro-Valenzuela J, Adams A, Cryns N, Monsef I, Dresen A, Roheger M, Eggers C, Skoetz N, Kalbe E. Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2023 Jan 5;1(1):CD013856. doi: 10.1002/14651858.CD013856.pub2. |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |
| D001519 | Behavior |