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| Name | Class |
|---|---|
| Hospital Clinic of Barcelona | OTHER |
| Institut d'Investigacions Biomèdiques August Pi i Sunyer | OTHER |
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The purpose of this study is to investigate if individuals with a cannabis use disorder have an impaired cerebellar function by assessing possible alterations to their implicit adaptation during a visuomotor rotation task.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental Explicit | Experimental | Cannabis user performs visuo-motor rotation tasks informed of an explicit strategy to maximise performance |
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| Control Explicit | Active Comparator | Healthy subject performs visuo-motor rotation tasks informed of an explicit strategy to maximise performance |
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| Experimental Implicit | Experimental | Cannabis user performs visuo-motor rotation tasks without being informed of the explicit strategy |
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| Control Implicit | Active Comparator | Healthy subject performs visuo-motor rotation tasks without being informed of the explicit strategy |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Visuo-motor rotation | Behavioral | Participant moves a cursor on a screen by sliding a pen over a digital tablet. Participants perform a center-out movement, aiming to a target that appears over one of a set of eight markers radially distributed. In several block of trials, the mapping of the pen position to the cursor is rotated. |
| Measure | Description | Time Frame |
|---|---|---|
| Directional error of hand trajectories towards a target | 1 day (a single session) |
| Measure | Description | Time Frame |
|---|---|---|
| Reaction times | 1 day (a single session) | |
| Intrinsic Motivational Inventory | 1 day (a single session) |
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Inclusion Criteria:
Exclusion Criteria:
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20697860 | Background | Taylor JA, Klemfuss NM, Ivry RB. An explicit strategy prevails when the cerebellum fails to compute movement errors. Cerebellum. 2010 Dec;9(4):580-6. doi: 10.1007/s12311-010-0201-x. | |
| 16597717 | Background | Mazzoni P, Krakauer JW. An implicit plan overrides an explicit strategy during visuomotor adaptation. J Neurosci. 2006 Apr 5;26(14):3642-5. doi: 10.1523/JNEUROSCI.5317-05.2006. |
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| ID | Term |
|---|---|
| D002189 | Marijuana Abuse |
| ID | Term |
|---|---|
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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| Explicit strategy | Behavioral | Participant is provided with an explicit instruction as to how counteract the effects of the visuo-motor rotation via aiming to a marker adjacent target |
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