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| Name | Class |
|---|---|
| Hospital de la Esperanza | UNKNOWN |
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Cognitive rehabilitation is defined as a systematic functionally oriented intervention of therapeutic cognitive activities based on the assessment and understanding of patient's brain behavior deficits. This project focuses on restoring cognitive functions in order to understand the underlying deficits in the patient's brain by developing integrated cognitive rehabilitation scenarios in virtual reality that combine memory, attention and problem solving training with context specific motor movements.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cognitive rehabilitation group | Experimental | Cognitive rehabilitation training with RGS in the clinic. |
|
| Passive control group | Active Comparator | Passive/conventional cognitive training at home. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cognitive rehabilitation training with RGS in the clinic | Behavioral | Daily cognitive training with the Rehabilitation Gaming System (RGS) in the clinic during 6 weeks (5 days per week a 30 minutes). |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Digit Span Forward WAIS-IV from baseline to end of treatment and to follow-up | Measurement of attention | Measured at baseline, at 6 weeks (end of treatment), and at 3-months (follow-up) |
| Change in Corsi block tapping test from baseline to end of treatment and to follow-up | Measurement of attention | Measured at baseline, at 6 weeks (end of treatment), and at 3-months (follow-up) |
| Change in Trail Making Test, Part A from baseline to end of treatment and to follow-up | Measurement of attention | Measured at baseline, at 6 weeks (end of treatment), and at 3-months (follow-up) |
| Change in Rey Auditory Verbal Learning Test from baseline to end of treatment and to follow-up | Measurement of episodic memory | Measured at baseline, at 6 weeks (end of treatment), and at 3-months (follow-up) |
| Change in Digit Span Backward WAIS-IV from baseline to end of treatment and to follow-up | Measurement of working memory | Measured at baseline, at 6 weeks (end of treatment), and at 3-months (follow-up) |
| Change in Corsi block-tapping test reversed from baseline to end of treatment and to follow-up | Measurement of working memory | Measured at baseline, at 6 weeks (end of treatment), and at 3-months (follow-up) |
| Change in Frontal Assessment Battery from baseline to end of treatment and to follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Montreal Cognitive Assessment from baseline to end of treatment and to follow-up | Measurement of global cognitive ability | Measured at baseline, at 6 weeks (end of treatment), and at 3-months (follow-up) |
| Change in Mini-Mental State Examination from baseline to end of treatment and to follow-up |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Esther Duarte Oller, MD, PhD | Parc de Salut Mar - Hospital de l'esperança | Principal Investigator |
| Paul F.M.J. Verschure, PhD | Director Specs | Study Director |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21440699 | Background | Cicerone KD, Langenbahn DM, Braden C, Malec JF, Kalmar K, Fraas M, Felicetti T, Laatsch L, Harley JP, Bergquist T, Azulay J, Cantor J, Ashman T. Evidence-based cognitive rehabilitation: updated review of the literature from 2003 through 2008. Arch Phys Med Rehabil. 2011 Apr;92(4):519-30. doi: 10.1016/j.apmr.2010.11.015. | |
| 12425704 |
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| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| ID | Term |
|---|---|
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| C000727727 | PITX2 protein, human |
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| Passive/conventional cognitive training at home. | Behavioral | Daily conventional cognitive rehabilitation at home as recommended by the neurologist during 6 weeks (5 days per week a 30 minutes). |
|
Measurement of executive functioning |
| Measured at baseline, at 6 weeks (end of treatment), and at 3-months (follow-up) |
| Change in Trail Making Test, Part B from baseline to end of treatment and to follow-up | Measurement of set-shifting | Measured at baseline, at 6 weeks (end of treatment), and at 3-months (follow-up) |
| Change in Digit Symbol Coding in WAIS-IV from baseline to end of treatment and to follow-up | Measurement of processing speed | Measured at baseline, at 6 weeks (end of treatment), and at 3-months (follow-up) |
| Change in Star Cancellation test from baseline to end of treatment and to follow-up | Measurement of spatial neglect | Measured at baseline, at 6 weeks (end of treatment), and at 3-months (follow-up) |
Measurement of global health status |
| Measured at baseline, at 6 weeks (end of treatment), and at 3-months (follow-up) |
| Change in Barthel Index from baseline to end of treatment and to follow-up | Measurement of independent functioning and mobility in activities of daily living | Measured at baseline, at 6 weeks (end of treatment), and at 3-months (follow-up) |
| Change in Fugl-Meyer Assessment from baseline to end of treatment and to follow-up | Measurement of motor recovery after stroke | Measured at baseline, at 6 weeks (end of treatment), and at 3-months (follow-up) |
| Ball K, Berch DB, Helmers KF, Jobe JB, Leveck MD, Marsiske M, Morris JN, Rebok GW, Smith DM, Tennstedt SL, Unverzagt FW, Willis SL; Advanced Cognitive Training for Independent and Vital Elderly Study Group. Effects of cognitive training interventions with older adults: a randomized controlled trial. JAMA. 2002 Nov 13;288(18):2271-81. doi: 10.1001/jama.288.18.2271. |
| 25741721 | Background | Corbetta M, Ramsey L, Callejas A, Baldassarre A, Hacker CD, Siegel JS, Astafiev SV, Rengachary J, Zinn K, Lang CE, Connor LT, Fucetola R, Strube M, Carter AR, Shulman GL. Common behavioral clusters and subcortical anatomy in stroke. Neuron. 2015 Mar 4;85(5):927-41. doi: 10.1016/j.neuron.2015.02.027. |
| 17636703 | Background | Nair RD, Lincoln NB. Cognitive rehabilitation for memory deficits following stroke. Cochrane Database Syst Rev. 2007 Jul 18;(3):CD002293. doi: 10.1002/14651858.CD002293.pub2. |
| 32143674 | Derived | Maier M, Ballester BR, Leiva Banuelos N, Duarte Oller E, Verschure PFMJ. Adaptive conjunctive cognitive training (ACCT) in virtual reality for chronic stroke patients: a randomized controlled pilot trial. J Neuroeng Rehabil. 2020 Mar 6;17(1):42. doi: 10.1186/s12984-020-0652-3. |