The objective of the study is to assess the safety, tolerance, food effect, pharmacokinetic and pharmacodynamic properties of single dose adminstration of SHR4640 in healthy volunteers.

Inclusion Criteria:

• Body weight≥50, BMI:19-24kg/m2;
• Screening serum urate level ≤ 4.5 mg/dL for male and ≤ 3.5 mg/dL for female;
• Medically stable based on physical examination, medical history, laboratory results, vital sign measurements, and 12-lead electrocardiogram (ECG) at screening;

Exclusion Criteria:

• History of hyperuricemia or gout.
• Pregnancy or breastfeeding;
• History or suspicion of kidney stones;
• serum creatinine>1.5mg/dl for male, >1.2mg/dl for female;
• alanine aminotransferase and/or aspartate aminotransferase>2 upper limit of normal, or total bilirubin>2.5 upper limit of normal.