The Metabolite Identification and Material Balance Study of SP2086

A Single-center, Randomized, Open, Single Dose Phase I Study to Access the Metabolite Identification and Material Balance in Health Volunteer

The purpose of the study is to investigate the Metabolite identification and material balance of SP2086 in healthy adult volunteers.

All subjects were given SP2086 100mg only one time, and blood sample should be collected before and 96 hours after medicine taken.

Inclusion Criteria:

• Healthy volunteers with a body mass index(BMI) between 19 and 25 Kg/m2,and weight ≥50kg.
• Lab and other examination results were normal or mildly abnormal without clinical significance, clinical doctors had considered eligible.
• Had signed the informed consent himself or herself voluntarily.

Exclusion Criteria:

• Has a history of severe system disease, or family history (including the cardiovascular system, digestive system, urinary system, etc.).
• Has a history of allergy or intolerance to SP2086 OR other DPP-IV.
• The subjects participated 3 times or more than 3 times drug clinical subjects in nearly a year;participate any drug clinical trial prior to the test 3 months, or had blood donor, or plan to blood donors three months before the test;or had a transfusion in 4 weeks.
• Did not take effective contraceptive measures or planning of the subjects in half a year.
• Researchers considered the patient adherence is poor, or has any unfavorable factors that not suit to participate the test.