The purpose of the present study is to evaluate the safety and exploratory efficacy of the umbilical cord mesenchymal stem cells for patients with fracture and bone nonunion.

Inclusion Criteria:

• Every patient with non union in the site of bone fracture and nonunion.
• Age more than 18 and less than 60 years old.
• Nonunion or delayed union.

Exclusion Criteria:

• Diagnosis of cancer.
• Pregnancy or breastfeeding.
• Patient positive by serology or PCR for HIV, hepatitis B or C infection the patient with Accompanied fracture such as hip fracture that could not weight bearing.
• Any medical or psychiatric condition that in the researcher´s opinion could affect the patient´s ability to complete the trial or hamper the participation in the trial.
• Patients do not sign the consent forms