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Action slowing has been demonstrated in many diseases. Parkinson's disease (PD) and Huntington's disease (HD) are two neurodegenerative diseases affecting the basal ganglia, particularly the medial globus pallidus, and the clinical expression of these two diseases is characterized by a combination of motor and cognitive disorders, but with two opposing patterns of dysfunction. Action slowing has been demonstrated in both of these diseases and has been extensively studied in Parkinson's disease, suggesting a perceptive-cognitive origin. Far fewer studies have been conducted in Huntington's disease. However, all of these studies were performed with different methodologies in small cohorts and the value of the proposed study is to use a validated and standardized computerized mental chronometry paradigm, providing a better understanding of the mechanisms of action slowing in these two diseases and to more clearly define a disease-specific profile.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Parkinson best-On | two hours after taking two tablets of 125 mg dispersible Modopar® |
| |
| Parkinson worst-off | after a drug withdrawal period ( morning fasting all dopaminergic treatment since the day before midnight) |
| |
| Huntington |
| ||
| Control | Data collected from the existing database |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| SRT | Behavioral | simple reaction time ( SRT) defined as the fastest response time to a target stimulus ( phase "worst -off" at the Parkinson's patient ) |
|
| Measure | Description | Time Frame |
|---|---|---|
| SRT | simple reaction time ( SRT) defined as the fastest response time to a target stimulus ( phase "worst -off" at the Parkinson's patient ) | Day 0 |
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Inclusion Criteria:
Agreeing to participate in the study
French mother tongue
MMSE > 20/30
Specific to the MP and MH:
Parkinson's disease:
Huntington disease :
Exclusion Criteria:
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Patients with Hoehn and Yahr stage 1 to 3 Parkinson's disease and patients with Shoulson stage I and II Huntington's disease, in whom admission to the Neurology ward is scheduled in the context of their follow-up, comprising a neuropsychological assessment (together with an acute L-dopa administration test for Parkinsonian patients) will be included
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| Name | Affiliation | Role |
|---|---|---|
| Pierre KRYSTKOWIAK, MD, PhD | CHU Amiens | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Amiens | Amiens | 80054 | France |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| D006816 | Huntington Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |
| D003704 | Dementia |
| D002819 | Chorea |
| D020820 | Dyskinesias |
| D020271 | Heredodegenerative Disorders, Nervous System |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |