To evaluate the acute effect of a preload of sucralose in presence of carbohydrate (HC) available on the glycemic response, postprandial C peptide and satiety in patients with type 2 diabetes mellitus (DM2) in intensive insulin therapy (IIT).

Inclusion Criteria:

• Minimum period of six month intensive insulin therapy
• Prescription rapid insulin in the breakfast
• Aged 35 to 70 years
• BMI 25 to 39.9 kg / m2
• HbA1c lower than or equal to 10% (86 mmol / mol)
• Menopausal women under hormone replacement therapy

Exclusion Criteria:

• History of intolerance artificial sweetener sucralose
• Pregnant women
• Puerperal women
• Subjects with neurological disease, endocrine disorder no treatment, kidney disease stage IV or V, cancer, liver disease, chronic obstructive pulmonary disease, HIV
• Subjects with history of stroke , acute myocardial infarction and gastrointestinal resection