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The aim of this study is to evaluate early clotting disorders through thromboelastogram and anticoagulant proteins levels (maybe also endothelial markers) and liver function by indocyanine green clearance after major liver resection and search for a potential relationship between them.
We are prospectively recording data from patients undergoing major liver resection. We obtain a full procoagulant and anticoagulant profile preoperatively and, at first, second and sixth day after surgery. We also measure indocyanine green (ICG) clearance preoperatively and in the first two postoperative days. We are also recording clinical data, focusing on medical and surgical complications. We aim to establish the potential value of ICG clearance and or coagulation profile to predict clinical complications
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| IGC and thromboelastometry | Patients that have hyper, normo o hypcoagulability measured by tromboelastometry and anticoagulant proteins levels early after major liver resection and clinical evolution and patients with liver funcion impairment or without it, measured by indocyanine green clearance early after surgery and clinical evolution |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Indocyanine green clearance | Drug | To evaluate liver function by injection of indocyanine green by a peripheral vein and measure its clearance |
|
| Measure | Description | Time Frame |
|---|---|---|
| Establish a relationship between ICG and MCF | We aim to find a potential association between ICG and MCF measured by thromboelastometry in the first week after surgery | 1 week |
| Establish a relationship between pro and anticoagulant proteins levels and endothelial markers | We aim to find a potential association between procoagulant factor levels, protein C,S and ATIII with thrombomodulin, heparan sulfate and syndecan-1 in the first week after surgery | 1 week |
| Measure | Description | Time Frame |
|---|---|---|
| Study blood coagulation disorders after major liver surgery resection | We aim to characterize blood coagulation disorders during the first week after major liver surgery in our sample of patients | 2 years |
| Study liver function after major liver surgery |
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Inclusion Criteria:
Exclusion Criteria:
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Patients undergoing major liver surgery defined as resection of 3 or more hepatic segments
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| Name | Affiliation | Role |
|---|---|---|
| Luis Olmedilla, PhD | Gregorio Marañon Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gregorio Marañon Hospital | Madrid | 28007 | Spain |
Publishing results
From december 2018
For other researchers and editors
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| ID | Term |
|---|---|
| D048550 | Hepatic Insufficiency |
| D001778 | Blood Coagulation Disorders |
| ID | Term |
|---|---|
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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| ID | Term |
|---|---|
| D013916 | Thrombelastography |
| ID | Term |
|---|---|
| D001780 | Blood Coagulation Tests |
| D006403 | Hematologic Tests |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
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Blood samples for anticoagulant proteins levels analysis and thromboelastometry
|
| Thromboelastometry | Other | To evaluate blood coagulation impairment by obtaining blood sample from a peripheral vein and measure anticoagulant proteins levels plus obtaining thromboelastometry |
|
We aim to study the predictive value of indocyanine green clearance for liver impairment after major liver surgery in our sample of patients |
| 2 years |
| D003933 | Diagnosis |
| D008919 | Investigative Techniques |