Major Liver Resection: Early Clotting Disorders and Functional Impairment.

Hypercoagulability and Liver Function After Major Liver Resection

The aim of this study is to evaluate early clotting disorders through thromboelastogram and anticoagulant proteins levels (maybe also endothelial markers) and liver function by indocyanine green clearance after major liver resection and search for a potential relationship between them.

We are prospectively recording data from patients undergoing major liver resection. We obtain a full procoagulant and anticoagulant profile preoperatively and, at first, second and sixth day after surgery. We also measure indocyanine green (ICG) clearance preoperatively and in the first two postoperative days. We are also recording clinical data, focusing on medical and surgical complications. We aim to establish the potential value of ICG clearance and or coagulation profile to predict clinical complications

Inclusion Criteria:

• Patients undergoing major liver surgery defined as resection of 3 or more hepatic segments

Exclusion Criteria:

• Indocyanin green allergy
• Thyrotoxicosis
• Thrombophilia
• Lupus anticoagulant
• Coagulation factor deficiency
• Venous thromboembolism in the last 3 years
• Pulmonary thromboembolism in the last 3 years