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| ID | Type | Description | Link |
|---|---|---|---|
| 2015-A00864-45 | Other Identifier | ID-RCB number, ANSM |
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This study aims to understand the impact of time-of-the day on human myocardial tolerance to ischemia-reperfusion by exploring atrial myocardium biopsied during cardiac surgery. Patients scheduled for non-urgent cardiac surgery (coronary artery by-pas graft and/or aortic valve replacement) will be assigned to a morning or an afternoon cardiac surgery based on randomization. Myocardial biopsies will be explored in ex vivo conditions mimicking ischemia-reperfusion.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| morning group | Other | cardiac surgery scheduled in the morning |
|
| afternoon group | Other | cardiac surgery scheduled in the afternoon |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| cardiac surgery scheduled in the morning | Procedure | cardiac surgery scheduled in the morning |
|
| Measure | Description | Time Frame |
|---|---|---|
| ischemia reperfusion injury in ex vivo conditions | measurement of hs troponin T released by the myocardium samples in the superfusion solution after ex vivo conditions mimicking ischemia-reperfusion | the day of the myocardial biopsy |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| David Montaigne, MD, PhD | University Hospital, Lille | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Lille University Hospital | Lille | 59000 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29107324 | Result | Montaigne D, Marechal X, Modine T, Coisne A, Mouton S, Fayad G, Ninni S, Klein C, Ortmans S, Seunes C, Potelle C, Berthier A, Gheeraert C, Piveteau C, Deprez R, Eeckhoute J, Duez H, Lacroix D, Deprez B, Jegou B, Koussa M, Edme JL, Lefebvre P, Staels B. Daytime variation of perioperative myocardial injury in cardiac surgery and its prevention by Rev-Erbalpha antagonism: a single-centre propensity-matched cohort study and a randomised study. Lancet. 2018 Jan 6;391(10115):59-69. doi: 10.1016/S0140-6736(17)32132-3. Epub 2017 Oct 26. |
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| ID | Term |
|---|---|
| D015427 | Reperfusion Injury |
| D017202 | Myocardial Ischemia |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
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| cardiac surgery scheduled in the afternoon | Procedure | cardiac surgery scheduled in the afternoon |
|
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006331 | Heart Diseases |