No linger a clinically relevant research question

Does baseline impedance measured during the landmark phase of esophageal High resolution impedance manometry HRIM correlates with direct mucosal impedance measurement and discriminates GERD from non GERD patients?

Patients referred to the Mayo Clinic Rochester for a clinically indicated high resolution impedance manometry (HRIM), 24 hour impedance pH (MII-pH) study, and esophagogastroduodenoscopy (EGD) will be recruited. Gastroesophageal reflux will be defined as a total 24 hour esophageal acid exposure time ≥5% regardless of concomitant Proton Pump inhibitor (PPI) use. A negative 24 hour MII-pH study will be defined as an acid exposure time ≤2% off PPI therapy or ≤1% if on PPI therapy.

Patients being seen at Mayo clinic Rochester having a clinically indicated endoscopy, a high resolution impedance manometry and a 24 hour pH impedance study.

Inclusion criteria:

• Adults ages 18-90
• Patients scheduled for or have completed a HRIM ( within 5 days)
• Patients scheduled for or recently have completed a MII-pH studies ( within 5 days)
• Patients scheduled for EGD

Exclusion criteria:

• Technically limited esophageal HRIM or MII-pH study
• Patients with HRIM and MII-pH studies not performed within 5 days of each other
• Patients with EGD not performed within 30 days of HRIM and MII-pH studies
• Medical conditions such as severe heart or lung disease that preclude safe performance of endoscopy
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