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Refeeding is an extracorporeal stool transport from the proximal stoma end to the distal end of stoma. Refeeding may be beneficial in preventing malabsorption, electrolyte imbalance, cholestasis and atrophy of the distal intestine. Investigators are focused on evaluating the efficacy and safety of the practice of refeeding in preterm infants with enterostomy. Clinical data including weight gain, total parenteral nutrition (TPN) usage, and other laboratory findings will be collected. Serial citrulline levels during refeeding procedure and pathologic specimens of bowel (at the time of stoma closure) will be collected for evaluating bowel adaptation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| The refeeding group | Experimental | Refeeding is initiated when 120mL/kg/day of enteral feed reaches or stoma loss exceeds more than 40ml/kg/day after operation. |
|
| The control group | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Refeeding | Procedure | when amount of feeding reach to 120mL/kg a day, |
|
| Measure | Description | Time Frame |
|---|---|---|
| The change of citrulline level during the study period | 4 time points: at the time of full enteral feeding (>120 cc/kg/day), 4 weeks later after full enteral feeding, at the time of stoma closure operation, 12 weeks later after closure operation | up to 6 months of corrected age |
| Measure | Description | Time Frame |
|---|---|---|
| The pathologic findings after refeeding procedure | villus height, crypt depth, mucosal thickening of pathologic specimens at the time of stoma closure operation | up to 8 weeks of corrected age |
| the number of days on parenteral nutrition |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | 03080 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36991415 | Derived | Lee ES, Kim EK, Shin SH, Jung YH, Song IG, Kim YJ, Kim HY, Choi YH, Moon KC, Kim B. Efficacy and safety of mucous fistula refeeding in preterm infants: an exploratory randomized controlled trial. BMC Pediatr. 2023 Mar 29;23(1):137. doi: 10.1186/s12887-023-03950-1. |
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| ID | Term |
|---|---|
| C575678 | RIFL protein, mouse |
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the day of discontinuation of intravenous protein supplements
| up to 8 weeks of corrected age |
| The weight gain | differences in the admission weight Z-scores and end of study weight Z-scores | up to 6 months of corrected age |
| Adverse events during refeeding procedure | bowel prolapse, enteral hemorrhage, abdominal distension, infection related stoma | up to 8 weeks of corrected age |