Testing the Interactive Effects of Delta-9-Tetrahydrocannabinol and Pregnenolone: Sub-Study I

Testing the Interactive Effects of Delta-9-Tetrahydrocannabinol and Pregnenolone: Sub-Study I

The overall purpose of this study is to examine the effect of Pregnenolone (PREG) on the acute psychosis-like and cognitive effects of Delta-9-Tetrahydrocannabinol (THC). This will be tested by pretreating healthy individuals with PREG, and then assessing their responses to Dronabinol (THC).

Inclusion Criteria:

• Exposed to cannabis at least once in lifetime

Exclusion Criteria:

• Cannabis naïve
• Individuals with a documented reaction/allergy to Pregnenolone
• Individuals with a documented reaction/allergy to Sesame oil