Motor Slowing and Its Lesion-related Correlates in Alzhei... | NCT02811653

Studies
Motor Slowing and Its Lesion-related Correlates in Alzheimer's Disease

NCT02811653

Sponsor

Centre Hospitalier Universitaire, Amiens

Status

Recruiting

Last Update Posted

May 28, 2026Actual

Enrollment

155Estimated

Phase

Not Applicable

Conditions

Alzheimer Disease

Interventions

Brain MRI
neuropsychological evaluation
Blood

Countries

France

Protocol Section

Identification Module Status Module Sponsor/Collaborators Module Oversight Module Description Module Conditions Module Design Module Arms/Interventions Module Outcomes Module Eligibility Module Contacts/Locations Module References Module IPD Sharing Statement Module

Results Section

Participant Flow Module Baseline Characteristics Module Outcome Measures Module Adverse Events Module More Info Module

Annotation Section

Annotation Module

Document Section

Large Document Module

Derived Section

Miscellaneous Info Module Condition Browse Module Intervention Browse Module

Protocol Section

Identification Module

NCT ID

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Version Holder

Status Module

Record Verification Date

May 2026

Overall Recruitment Status or Expanded Access Status

Recruiting

Last Known Status

Not provided

Delayed Posting

Not provided

Why Stopped

Not provided

Expanded Access Info

Start Date

Dec 16, 2015Actual

Primary Completion Date

Dec 16, 2028Estimated

Completion Date

Dec 16, 2028Estimated

First Submitted Date

Jun 16, 2016

First Submission Date that Met QC Criteria

Jun 22, 2016

First Posted Date

Jun 23, 2016Estimated

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

May 27, 2026

Last Update Posted Date

May 28, 2026Actual

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Alzheimer disease	Experimental	Alzheimer disease patients Brain MRI (Magnetic Resonance Imaging) Blood neuropsychological evaluation	Device: Brain MRI Other: neuropsychological evaluation Biological: Blood
control	Active Comparator	Healthy age- and gender-matched volunteers will be recruited into the study from the general population. Brain MRI (Magnetic Resonance Imaging) Blood neuropsychological evaluation	Device: Brain MRI Other: neuropsychological evaluation Biological: Blood

Interventions

Name	Type	Description	Arm Group Labels	Other Names
Brain MRI	Device		Alzheimer disease control
neuropsychological evaluation

Measure	Description	Time Frame
median SRT (simple reaction time) to a stimulus (in milliseconds)		Day 0

Eligibility Module

Eligibility Criteria

Inclusion Criteria:

Patients
- Age between 40 and 85
- French mother tongue
- Consulting at the Amiens Memory Resource and Research Centre (CMRR) for:
- MCI, according to Albert et al.'s criteria (Albert et al., 2011)
- Mild dementia (MMSE>20) due to AD, according to McKhann's criteria (McKhann et al., 2011).
- Mild dementia due to LBD, according to McKeith et al.'s criteria (McKeith et al., 2005).
- Mild dementia due to FTLD, according to Rascovsky et al.'s criteria (Rascovsky et al., 2011).
- Social security coverage
Healthy controls
- Healthy age and gender matched volunteers will be recruited into the study from the general population.

Exclusion Criteria:

Reading or writing difficulties related to a learning disorder or illiteracy.
A medical history with a potentially significant impact on cognition (non-corrected thyroid disorders or heart failure):
- NYHA stage IV dyspnoea.
- respiratory impairment requiring oxygen therapy.
- liver impairment.
- kidney failure, progressing neoplastic disease, or past or present alcohol abuse.
Past or present neurological disorders other than those having prompted consultation in the Memory Clinic:
- stroke.
- meningitis or encephalitis.
- severe head injury.
- sensorimotor impairments (sensory, proprioceptive, cerebellar and visual impairments).
- epilepsy (requiring ongoing treatment),
- psychiatric disorders (other than treated depression).
- treatment with psychotropic medications (other than anxiolytics or antidepressant withdrawn or initiated in the previous month). Patients with parkinsonian syndrome were examined in the "on-drug" state.
Impossibility to perform a neuropsychological evaluation or brain MRI.
Withdrawal from the study at any time, if desired.
Pregnancy
Contra-indication to MRI:
- nerve stimulators
- cochlear implants
- ferromagnetic foreign bodies close to nervous structures in the eye or brain
- cerebral shunts
- dental appliances
Legal guardianship or incarceration.

Accepts Healthy Volunteers

Yes

Sex

All

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

40 Years

Maximum Age

85 Years

Standard Ages

AdultOlder Adult

Study Population

Not provided

Sampling Method

Not provided

ID	Term
D003704	Dementia
D001927	Brain Diseases
D002493	Central Nervous System Diseases
D009422	Nervous System Diseases

ID	Term
D013048	Specimen Handling
D019411	Clinical Laboratory Techniques
D019937	Diagnostic Techniques and Procedures
D003933	Diagnosis