Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Deficiency in gonadal hormone has been considered to play a role in ageing related increased incidence of cardiovascular events. But the mechanism has not been fully elucidated. On the other hand, the dramatic increase in gonadotropin level didn't drew much attention when talking about the increased risk of cardiovascular disease during menopausal transition. This study aim to investigate the association between gonadal hormone, gonadotropin and long-term cardiovascular events.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| female, premenopause | Women with regular menstrual cycles in normal range (22-35 days) for the previous three cycles. | ||
| female, perimenopause | Peri-menopause was defined as the presence of menses within the past 3 months with a decrease in cycle predictability in the year preceding examination or 3-11 months of amenorrhea. To investigate the association between serum FSH and cholesterol levels independent of E2, we further selected peri-menopausal subjects with the presence of menses within the past 3 months with a decrease in cycle predictability in the year preceding examination because their E2 levels have been reported to be similar to those in pre-menopause. | ||
| Serum FSH level Quartile 1 | Serum FSH level: <6.95 mIU/mL | ||
| Serum FSH level Quartile 2 | Serum FSH level: 6.95-10.87 mIU/mL | ||
| Serum FSH level Quartile 3 | Serum FSH level: 10.88-25.45 mIU/mL | ||
| Serum FSH level Quartile 4 | Serum FSH level: >25.45 mIU/mL |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Rate of first cardiovascular disorder events | Total incidence rate from cardiovascular disorder over a given period of time | Measured after 10 years of follow-up |
| Cardiovascular disease mortality | Total deaths from cardiovascular disease over a given period of time | Measured after 10 years of follow-up |
| All-cause mortality | Total deaths from all causes over a given period of time | Measured after 10 years of follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| Change in serum lipid levels | Include triglycerides、cholesterol、 low density lipoprotein cholesterol、 high density lipoprotein cholesterol. | Measured at baseline, and every 2 years during the 10-year follow-up period |
| Change in thickness of blood vessel wall |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Adults aged of 18 to 75 years old. Part of the subjects (aged 40 years or more) were selected from REACTION study that was conducted from April,1, 2011 through May 30, 2012, aiming to investigate the epidemiology of metabolic diseases across China. The younger participants were recruited since July 1, 2014.
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Jiajun Zhao | Shandong Provincial Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shandong Provincial Hospital | Jinan | Shandong | 250021 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30559440 | Background | Guo Y, Zhao M, Bo T, Ma S, Yuan Z, Chen W, He Z, Hou X, Liu J, Zhang Z, Zhu Q, Wang Q, Lin X, Yang Z, Cui M, Liu L, Li Y, Yu C, Qi X, Wang Q, Zhang H, Guan Q, Zhao L, Xuan S, Yan H, Lin Y, Wang L, Li Q, Song Y, Gao L, Zhao J. Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol. Cell Res. 2019 Feb;29(2):151-166. doi: 10.1038/s41422-018-0123-6. Epub 2018 Dec 17. |
| Label | URL |
|---|---|
| NCBI link | View source |
Not provided
Not provided
| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
| D009765 | Obesity |
| D050197 | Atherosclerosis |
| D044882 | Glucose Metabolism Disorders |
| D024821 | Metabolic Syndrome |
| D065626 | Non-alcoholic Fatty Liver Disease |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Serum，Plasma and Whole blood
The mean carotid Intima media thickness showed the early risk of atherosclerotic cardiovascular diseasean. the subclinical atherosclerosis was defined as the mean carotid Intima media thickness ≥0.78mm. |
| Measured at baseline, and every 2 years during the 10-year follow-up period |
| Number of participants that diagnosed with metabolic syndrome | Metabolic syndrome refers to the pathological state in which protein, fat, carbohydrate and other substances in human body have metabolic disorders. It is a group of complex metabolic disorders and a risk factor leading to cardiovascular and cerebrovascular diseases of diabetes. | Measured at baseline, and every 2 years during the 10-year follow-up period |
| Number of participants that diagnosed with non-alcoholic fatty liver disease | A clinicopathological syndrome characterized by excessive deposition of fat in liver cells due to alcohol and other clearly damaging factors is excluded | Measured at baseline, and every 2 years during the 10-year follow-up period |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D008659 | Metabolic Diseases |
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D005234 | Fatty Liver |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |