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The purpose of this study is to investigate the association between pre-existing microalbuminuria and contrast-induced acute kidney injury (CIAKI) following coronary angiography (CAG).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| microalbuminuria with eGFR≥60ml/min | microalbuminuria group with estimated glomerular filtration rate (eGFR) ≥60ml/min. |
| |
| normal-albuminuria group with eGFR≥60ml/min | normal-albuminuria group with estimated glomerular filtration rate (eGFR) ≥60ml/min. | ||
| microalbuminuria group with eGFR<60ml/min | microalbuminuria group with estimated glomerular filtration rate (eGFR) <60ml/min. |
| |
| normal-albuminuria group with eGFR<60ml/min | normal-albuminuria group with estimated glomerular filtration rate (eGFR) <60ml/min. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| microalbuminuria | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| changes of serum creatinine (SCr, umol/L) | the difference of SCr before and after CAG. | 24-48 hours after CAG |
| number of participants with increase in SCr of at least 44.2 umol/L higher than before | number of participants with the difference of SCr before and after CAG over 44.2 umol/L. | 24-48 hours after CAG |
| number of participants with increase of SCr over 25% higher than before | number of participants with an increase of SCr over 25% higher than before. | 24-48 hours after CAG |
| Measure | Description | Time Frame |
|---|---|---|
| changes of urine albumin to creatinine ratio (ACR, mg/g) | the difference of ACR before and after CAG | 24-48 hours after CAG |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with eGFR ≥ 30 ml/min and without macroalbuminuria (defined as urine albumin to creatinine ratio (ACR) >300 mg/g) on admission are prepared to accept scheduled invasive coronary angiography during hospitalization.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Zhijian Yang, Doctor | Contact | +86 13809030208 | zhijianyangnj@njmu.edu.cn | |
| Haoyu Meng, Master | Contact | +86 15805167259 | 15805167259@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Zhijian Yang, Doctor | First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| First Affiliated Hospital of Nanjing Medical University | Nanjing | Jiangsu | 210029 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17975790 | Background | Pucelikova T, Dangas G, Mehran R. Contrast-induced nephropathy. Catheter Cardiovasc Interv. 2008 Jan 1;71(1):62-72. doi: 10.1002/ccd.21207. | |
| 16949481 | Background | Jo SH, Youn TJ, Koo BK, Park JS, Kang HJ, Cho YS, Chung WY, Joo GW, Chae IH, Choi DJ, Oh BH, Lee MM, Park YB, Kim HS. Renal toxicity evaluation and comparison between visipaque (iodixanol) and hexabrix (ioxaglate) in patients with renal insufficiency undergoing coronary angiography: the RECOVER study: a randomized controlled trial. J Am Coll Cardiol. 2006 Sep 5;48(5):924-30. doi: 10.1016/j.jacc.2006.06.047. Epub 2006 Aug 17. |
| Label | URL |
|---|---|
| Click here for more information about this study: Microalbuminuria Predicting CIAKI After CAG | View source |
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| 19189906 | Background | Marenzi G, Assanelli E, Campodonico J, Lauri G, Marana I, De Metrio M, Moltrasio M, Grazi M, Rubino M, Veglia F, Fabbiocchi F, Bartorelli AL. Contrast volume during primary percutaneous coronary intervention and subsequent contrast-induced nephropathy and mortality. Ann Intern Med. 2009 Feb 3;150(3):170-7. doi: 10.7326/0003-4819-150-3-200902030-00006. |
| 12010907 | Background | Rihal CS, Textor SC, Grill DE, Berger PB, Ting HH, Best PJ, Singh M, Bell MR, Barsness GW, Mathew V, Garratt KN, Holmes DR Jr. Incidence and prognostic importance of acute renal failure after percutaneous coronary intervention. Circulation. 2002 May 14;105(19):2259-64. doi: 10.1161/01.cir.0000016043.87291.33. |
| 19444480 | Background | Cronin RE. Contrast-induced nephropathy: pathogenesis and prevention. Pediatr Nephrol. 2010 Feb;25(2):191-204. doi: 10.1007/s00467-009-1204-z. Epub 2009 May 15. |
| 11904577 | Background | National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002 Feb;39(2 Suppl 1):S1-266. No abstract available. |
| 17053479 | Background | Lambers Heerspink HJ, Brinkman JW, Bakker SJ, Gansevoort RT, de Zeeuw D. Update on microalbuminuria as a biomarker in renal and cardiovascular disease. Curr Opin Nephrol Hypertens. 2006 Nov;15(6):631-6. doi: 10.1097/01.mnh.0000247496.54882.3f. |
| 16825333 | Background | Stehouwer CD, Smulders YM. Microalbuminuria and risk for cardiovascular disease: Analysis of potential mechanisms. J Am Soc Nephrol. 2006 Aug;17(8):2106-11. doi: 10.1681/ASN.2005121288. Epub 2006 Jul 6. |
| 19892066 | Background | Baber U, Mann D, Shimbo D, Woodward M, Olin JW, Muntner P. Combined role of reduced estimated glomerular filtration rate and microalbuminuria on the prevalence of peripheral arterial disease. Am J Cardiol. 2009 Nov 15;104(10):1446-51. doi: 10.1016/j.amjcard.2009.06.068. |
| 17667984 | Background | Bakris GL, Ruilope L, Locatelli F, Ptaszynska A, Pieske B, de Champlain J, Weber MA, Raz I. Treatment of microalbuminuria in hypertensive subjects with elevated cardiovascular risk: results of the IMPROVE trial. Kidney Int. 2007 Oct;72(7):879-85. doi: 10.1038/sj.ki.5002455. Epub 2007 Aug 1. |
| 24138570 | Background | Sany D, Refaat H, Elshahawy Y, Mohab A, Ezzat H. Frequency and risk factors of contrast-induced nephropathy after cardiac catheterization in type II diabetic patients: a study among Egyptian patients. Ren Fail. 2014 Mar;36(2):191-7. doi: 10.3109/0886022X.2013.843400. Epub 2013 Oct 21. |
| 27161053 | Result | Meng H, Wu P, Zhao Y, Xu Z, Wang ZM, Li C, Wang L, Yang Z. Microalbuminuria in patients with preserved renal function as a risk factor for contrast-Induced acute kidney injury following invasive coronary angiography. Eur J Radiol. 2016 Jun;85(6):1063-7. doi: 10.1016/j.ejrad.2016.03.010. Epub 2016 Mar 16. |
| Click here for more information about this study: Microalbuminuria Predicting CIAKI After CAG | View source |
| Click here for more information about this study: Microalbuminuria Predicting CIAKI After CAG | View source |
| Click here for more information about this study: Microalbuminuria Predicting CIAKI After CAG | View source |
| Click here for more information about this study: Microalbuminuria Predicting CIAKI After CAG | View source |