Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This is a study aimed to compare two materials: (1) Biodentine and (2) MTA. These two materials are going to be tested in sealing accidental root perforations at the bifurcation areas. The study is going to be conducted as a randomized controlled trial.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Biodentine | Experimental | The perforation area of the root is going to be covered by Biodentine |
|
| MTA | Active Comparator | The perforation area of the root is going to be covered by MTA. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Biodentine | Drug | Biodentine is going to be used as the sealing agent for the perforation. |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Success at 3 months following root sealing | Case is considered successful if clinical and radiographic examinations of the tooth are sound 100%. | The success of treatment is assessed at three months following the application of the material |
| Success at 6 months following root sealing | Case is considered successful if clinical and radiographic examinations of the tooth are sound 100%. | The success of treatment is assessed at 6 months following the application of the material |
| Success at 9 months following root sealing | Case is considered successful if clinical and radiographic examinations of the tooth are sound 100%. | The success of treatment is assessed at 9 months following the application of the material |
| Success at 12 months following root sealing | Case is considered successful if clinical and radiographic examinations of the tooth are sound 100%. | The success of treatment is assessed at 12 months following the application of the material |
| Success at 18 months following root sealing | Case is considered successful if clinical and radiographic examinations of the tooth are sound 100%. | The success of treatment is assessed at 18 months following the application of the material |
| Success at 24 months following root sealing | Case is considered successful if clinical and radiographic examinations of the tooth are sound 100%. | The success of treatment is assessed at 24 months following the application of the material |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Mohammad MN Aldakak, DDS MSc | PhD Student in Operative Dentistry | Principal Investigator |
| Souad Abboud, DDS MSc PhD | Associate Professor of Operative Dentistry, University of Damascus Dental School, Damascus, Syria | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Operative Dentistry, University of Damascus Dental School | Damascus | DM20AM18 | Syria |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23402511 | Background | Guneser MB, Akbulut MB, Eldeniz AU. Effect of various endodontic irrigants on the push-out bond strength of biodentine and conventional root perforation repair materials. J Endod. 2013 Mar;39(3):380-4. doi: 10.1016/j.joen.2012.11.033. Epub 2013 Jan 16. | |
| 16764130 | Background | Iwamoto CE, Adachi E, Pameijer CH, Barnes D, Romberg EE, Jefferies S. Clinical and histological evaluation of white ProRoot MTA in direct pulp capping. Am J Dent. 2006 Apr;19(2):85-90. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| C506393 | tricalcium silicate |
| D000068437 | Pemetrexed |
| ID | Term |
|---|---|
| D006147 | Guanine |
| D007042 | Hypoxanthines |
| D011688 | Purinones |
| D011687 | Purines |
| D006574 |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| MTA |
| Drug |
MTA is going to be used as the sealing agent for the perforation. |
|
| 22411260 | Background | Koubi G, Colon P, Franquin JC, Hartmann A, Richard G, Faure MO, Lambert G. Clinical evaluation of the performance and safety of a new dentine substitute, Biodentine, in the restoration of posterior teeth - a prospective study. Clin Oral Investig. 2013 Jan;17(1):243-9. doi: 10.1007/s00784-012-0701-9. Epub 2012 Mar 14. |
| 18448160 | Background | Laurent P, Camps J, De Meo M, Dejou J, About I. Induction of specific cell responses to a Ca(3)SiO(5)-based posterior restorative material. Dent Mater. 2008 Nov;24(11):1486-94. doi: 10.1016/j.dental.2008.02.020. Epub 2008 Apr 29. |
| 22892739 | Background | Zanini M, Sautier JM, Berdal A, Simon S. Biodentine induces immortalized murine pulp cell differentiation into odontoblast-like cells and stimulates biomineralization. J Endod. 2012 Sep;38(9):1220-6. doi: 10.1016/j.joen.2012.04.018. Epub 2012 Jul 24. |
| Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
| D005971 | Glutamates |
| D024342 | Amino Acids, Acidic |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |
| D000600 | Amino Acids, Dicarboxylic |