Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
For preoperative staging and prediction of peritoneal dissemination of gastric adenocarcinoma, usage of serum and peritoneal levels of carcinoembryonic antigen (CEA) and CA 19-9 may be helpful. Additionally, the prognosis of the patients with gastric adenocarcinoma treated with gastrectrectomy may be associated with serum and peritoneal levels of tumor markers.
Clinical usage of tumor markers on preoperative staging and prediction of peritoneal dissemination of gastric adenocarcinoma is a controversial issue. It has been thought that there is a positive correlation between serum and peritoneal levels of carcinoembryonic antigen (CEA) and CA 19-9 and pathologic features of gastric tumors and peritoneal dissemination.
In this study, it was aimed to evaluate the effect of serum and peritoneal CEA and CA 19-9 to predict TNM stages and peritoneal washing cytology in patients with gastric adenocarcinoma after curative gastrectomy, and to determine predictive value of these measurements to the development of recurrence and death.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| tumor marker | serum CEA and CA 19-9 levels in patients with curative gastrectomy preoperatively and peritoneal CEA and CA 19-9 levels in patients taken at the beginning of curative gastrectomy via sampling of peritoneal washing aspirate |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| gastrectomy | Procedure | radical total/subtotal gastrectomy with D2 lymph node dissection |
| |
| Measure | Description | Time Frame |
|---|---|---|
| TNM stage | TNM stage based on the 7th American Joint Committee on Cancer/International Union Against Cancer tumor, node, metastasis system. | through pathologic report completion, an average of 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| peritoneal washing cytology | detection of positive free peritoneal gastric adenocarcinoma cells. | through pathologic report completion, an average of 1 month |
| recurrence/death | detection of recurrence or development of death |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
gastric adenocarcinoma treated with curative gastrectomy
Not provided
| Name | Affiliation | Role |
|---|---|---|
| mustafa hasbahceci, assoc. prof. | bezmialem vakif university faculty of medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mustafa Hasbahceci | Istanbul | 34093 | Turkey (Türkiye) |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D005743 | Gastrectomy |
| ID | Term |
|---|---|
| D013505 | Digestive System Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
Not provided
Not provided
Not provided
Not provided
Not provided
| sampling of peritoneal washing aspirate |
| Procedure |
After thoroughly examination of the peritoneal cavity revealing the absence of peritoneal dissemination, the peritoneal cavity was washed with 200 ml of saline, and at least one third was aspirated from several regions of the peritoneal cavity, including near the primary tumor, the left and right subphrenic areas and the pouch of Douglas with suction tubes to a clean bottle and designated as the peritoneal sample for determination of peritoneal levels of CEA and CA 19-9. |
|
| through follow-up period, an average of 24 months |