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| Name | Class |
|---|---|
| Ajinomoto Co., Inc. | INDUSTRY |
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Protein requirements in individuals who participate in endurance-based exercise training have been suggested to be greater than the current recommended dietary allowance (RDA).
Our recent study using the minimally invasive indicator amino acid oxidation (IAAO) technique have suggested that protein requirements in young men are at least 30% higher than the recommended protein intake.
The present study will investigate the impact of protein sufficiency on protein metabolism and performance during intensified training periods as a means to further our understanding of the nutritional requirements for the endurance athlete.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal protein intake | Experimental | participants will receive the controlled-diet containing 0.8 g protein /kg/day and the test drink containing 0.14 g protein/kg/d. |
|
| Moderate protein intake | Experimental | participants will receive the controlled-diet containing 1.20 g protein /kg/day and the test drink containing 0.40 g protein/kg/d. |
|
| High protein intake | Experimental | participants will receive the controlled-diet containing 1.83 g protein /kg/day and the test drink containing 1.03 g protein/kg/d. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Normal | Dietary Supplement | test drink which contains low amount of amino acids (0.14 g/kg/day) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in 24h whole body protein balance | Protein balance (mg/kg/d; protein synthesis - protein breakdown) will be measured using [15N]Glycine method on day 1 and day 4 to determine the change over the intensified training period to compare between protein levels | Difference between day 1 and day 4 whole body protein balance |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline physical performance (5 km time trial) 5days after the beginning of training | Before and after 4 days of intensified training period, Duration (seconds) for completing 5-km running on treadmill will be measured. | 5days after the beginning of training |
| change from baseline Physical performance (muscle strength) 5days after the beginning of training |
| Measure | Description | Time Frame |
|---|---|---|
| Creatine Phosphate Kinase activity on day 5 | Muscle damage markers (blood Creatine Phosphate Kinase activity, IU/L) will be compared between the experimental arms 5days after the beginning of training | 5days after the beginning of training |
| Myoglobin concentration on day 5 |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Daniel Moore, Ph.D. | Faculty of Kinesiology and Physical Education, University of Toronto | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Goldring Centre For High Performance Sport | Toronto | Ontario | M5S 2C9 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36477889 | Derived | Williamson E, Kato H, Volterman KA, Suzuki K, Moore DR. Greater plasma essential amino acids and lower 3-methylhistidine with higher protein intake during endurance training: a randomised control trial. Amino Acids. 2023 Oct;55(10):1285-1291. doi: 10.1007/s00726-022-03210-z. Epub 2022 Dec 7. |
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| ID | Term |
|---|---|
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D001519 | Behavior |
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| Moderate | Dietary Supplement | test drink which contains moderate amount of amino acids (0.40 g/kg/day) |
|
| High | Dietary Supplement | test drink which contains high amount of amino acids (1.03 g/kg/day) |
|
| Controlled-diet | Other | the diet containing 0.8 g protein /kg/day |
|
Maximal strength will be assessed by a maximal isometric voluntary contraction (MVC), which will be tested for the knee-extensors using a custom-made knee-extension apparatus after 4 days intensified training. |
| 5days after the beginning of training |
| change from baseline Physical Performance (muscle power) 5days after the beginning of training | Peak lower body power will be measured by force platform after 4days-intensified training. | 5days after the beginning of training |
Muscle damage markers (blood Mb Concentration, mg/mL) will be compared between the experimental arms 5days after the beginning of training |
| 5days after the beginning of training |
| IL-6 concentration on day 5 | inflammatory markers (IL-6 concentration, pg/ml) will be compared between the experimental arms 5days after the beginning of training | 5days after the beginning of training |
| CRP concentration on day 5 | inflammatory markers (CRP concentration, mg/L) will be compared between the experimental arms 5days after the beginning of training | 5days after the beginning of training |
| amino acid concentration on day 5 | amino acid concentration (mmol/mL) will be compared between the experimental arms 5days after the beginning of training | 5days after the beginning of training |